中西医结合治疗女性更年期综合征的临床效果及对激素水平及免疫功能的影响  

The clinical effects of conbined treatment of traditional Chinese medicine and western medicine on female climacteric syndrome and its effect on hormone level and immune function of patients

作　　者：张滋[1] 刘肖莉[2] 刘照佩[2] 房晓萌[2] ZHANG Zi;LIU Xiaoli;LIU Zhaopei(Department of Traditional Chinese Medicine,The Third Hospital of Shijiazhuang City,Hebei,Shijiazhuang 050011, China)

机构地区：[1]河北省石家庄市第三医院中医科,050011 [2]河北省石家庄市第三医院心理科,050011

出　　处：《河北医药》2019年第10期1528-1531,共4页Hebei Medical Journal

基　　金：河北省中医药管理局科研计划项目(编号:2016217)

摘　　要：目的探讨中西医结合治疗女性更年期综合征的临床效果及对激素水平及免疫功能的影响。方法女性更年期综合征患者86例,随机分成对照组和研究组,每组43例。对照组口服戊酸雌二醇0.5 mg/d,研究组患者在此基础上口服舒肝颗粒3 g/次,3次/d,3个月为1个疗程。比较2组患者临床疗效,激素水平促卵泡激素、雌二醇、黄体生成素、焦虑抑郁量表[焦虑自评量表(SAS、抑郁自评量表(SDS)]以及免疫功能(CD^+_3、CD^+_4、CD^+_8)相关指标。结果研究组临床疗效显著优于对照组(P<0.05)。研究组临床有效率显著高于对照组(P<0.05)。2组患者Kupperman评分以及SAS,SDS评分均显著下降(P<0.05)。研究组患者Kupperman评分以及SAS,SDS评分均显著低于对照组(P<0.05)。2组患者雌二醇水平显著升高(P<0.05),研究组雌二醇水平显著高于对照组(P<0.05)。2组患者黄体生成素和促卵泡激素水平均显著降低(P<0.05)。研究组黄体生成素和促卵泡激素水平均显著低于对照组(P<0.05)。2组患者CD_3^+和CD_4^+水平均显著升高(P<0.05),研究组CD_3^+和CD_4^+水平均显著高于对照组。2组患者CD_8^+水平均显著下(P<0.05),研究组CD_8^+水平显著低于对照组(P<0.05)。2组患者在治疗期间均未见明显不良反应。结论舒肝颗粒联合戊酸雌二醇片治疗女性更年期综合征具有较显著的疗效,能明显减轻焦虑、抑郁症状,有效调节体内激素水平,提高免疫功能。Objective To investigate the clinical effects of conbined treatment of traditional Chinese medicine and western medicine on female climacteric syndrome and its effect on hormone level and immune function of patients. Methods A total of 86 female patients with climacteric syndrome who were treated in our hospital from June 2013 to June 2016 were randomly divided into control group and observation group,with 43 patients in each group.The patients in control group were treated by oral estradiol valerate tablets 0.5mg/d,however,the patients in observation group,on the basis of control group,were treated by Shugan granules 3g once, three times a day, with a treatment course of three months for both groups. The clinical efficacy, hormone levels,immune function indexes,SAS score and SDS score were observed and compared between the two groups. Results The clinical efficacy in observation group was significantly better than that in control group ( P <0.05),and the clinical effective rate in observation group was significantly higher than that in control group ( P <0.05).After treatment Kupperman scores, SAS scores and SDS scores in both groups were decreased significantly ( P <0.05),moreover,which in observation group were significantly lower than those in control group ( P <0.05). The levels of estradiol in both groups were increased significantly,moreover,which in observation group were significantly higher than those in control group ( P < 0.05 ). The levels of luteinizing hormone and follicle-stimulating hormone in both groups were decreased significantly ( P <0.05),moreover, which in observation group were significantly lower than those in control group ( P <0.05). In addition the levels of CD + 3 and CD + 4 in both groups were increased significantly ( P <0.05), moreover,which in observation group were significantly higher than those in control group. However the levels of CD 8 + in both groups were decreased significantly,moreover,which in observation group were significantly lower than those in control group ( P <

关 键 词：舒肝颗粒 戊酸雌二醇片 更年期综合征 激素水平 

分 类 号：R271.116[医药卫生—中医妇科学]