核因子κB信号通路在银屑病中的研究进展  

NF-κB signaling pathway in psoriasis

作　　者：潘家旭 周婧[1] Pan Jiaxu;Zhou Jing(Department of Dermatology,The Second Affiliated Hospital of Harbin Medical University,Harbin 150000,China)

机构地区：[1]哈尔滨医科大学附属第二医院皮肤性病科,150000

出　　处：《中华皮肤科杂志》2019年第5期361-363,共3页Chinese Journal of Dermatology

摘　　要：核因子κB是一种蛋白转录因子,介导炎症等复杂的生物学过程,是多种免疫和炎症通路以及细胞增殖、分化和凋亡的关键调节因子。银屑病是一种炎症性皮肤病,其特征之一是磷酸化核因子κB水平升高导致角质形成细胞抗凋亡能力增强,并加重炎症反应。本文概述核因子κB信号通路及其在银屑病中的研究进展。Nuclear factor (NF)-κB,a kind of protein transcription factor,mediates inflammation and other complex biological processes,and is a key regulator of many immune and inflammatory pathways,cell proliferation,differentiation and apoptosis.Psoriasis is an inflammatory skin disease characterized by increased levels of phosphorylated NF-κB,which leads to an increase in anti-apoptotic activity of keratinocytes and aggravation of inflammatory reactions.This review summarizes advances in NF-κB signaling pathway and its role in psoriasis.

关 键 词：银屑病 NF-ΚB 转录因子RelA 细胞增殖 细胞凋亡 IΚBΑ 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]