强脉冲光联合氢醌乳膏治疗黄褐斑的疗效  

Efficacy of intense pulsed light combined with hydroquinone cream to treat melisma

作　　者：余丕军[1] 郭吉安 王露萍[1] 石莹莹[1] 柳逸[1] 陈炜[1] Yu Pijun;Guo Ji-an;Wang Luping;Shi Yingying;Liu Yi;Chen Wei(Department of Plastic Surgery,Shanghai Eighth People's Hospital,Shanghai 200235,China)

机构地区：[1]上海市第八人民医院整形美容科,200235

出　　处：《中华医学美学美容杂志》2019年第2期140-142,共3页Chinese Journal of Medical Aesthetics and Cosmetology

基　　金：上海市卫生和计划生育委员会科研项目(20154Y0198).

摘　　要：目的评估强脉冲光联合氢醌乳膏治疗黄褐斑的有效性和安全性。方法对2015年2月至2017年2月在上海市第八人民医院整形美容科治疗的黄褐斑患者35例,强脉冲光联合氢醌乳膏治疗20例,单纯强脉冲光治疗15例。35例均为女性,Fitzpatrick皮肤分型为Ⅲ、Ⅳ型。35例患者4周治疗1次,5次为1个疗程。治疗后随访半年,通过患者满意度与医师评价对治疗有效性和安全性进行分析。结果35例患者治疗后均无不适,均得到有效随访。单纯强脉冲光治疗组患者满意率73.3%,强脉冲光联合氢醌乳膏治疗组满意率100%。两组满意度以强脉冲光联合氢醌乳膏治疗组为高。医师对35例患者治疗前后照片进行对比,单纯强脉冲光治疗组有效率53.3%,强脉冲光联合氢醌乳膏治疗组有效率85.0%。强脉冲光联合氢醌乳膏治疗组对治疗有效率和效果明显高于单纯强脉冲光治疗组(χ^2=4.09,P<0.05)。35例患者均未出现色素沉着等不良反应。结论强脉冲光联合氢醌乳膏治疗黄褐斑安全有效,患者满意度较高。Objective To evaluate the efficacy and safety of intense pulsed light(IPL)combined with hydroquinone cream for melasma treatment.Methods Thirty-five patients with melasma were treated between February 2015 and February 2017,20 patients treated with IPL combined with hydroquinone cream and 15 patients with IPL alone.All cases were female patients with Fitzpatrick skin typesⅢandⅣ,and subjected to 4 weeks treatment 1 time,5 times for a course of treatment.All patients were followed up for six months and the efficacy and safety of the treatment were analyzed comprehensively by subjective satisfaction and physician evaluation.Results All the patients were treated without discomfort and treated patients were effectively followed up.The satisfactory rate of IPL treatment group was 73.3%,and that of combined with hydroquinone cream group was 100%.Two groups of satisfactory rates were higher in IPL combined with hydroquinone cream.The total effective rate of the IPL treatment group was 53.3%compared with that of the 35 patients before and after treatment;in IPL combined with hydroquinone cream treatment group the total effective rate was 85.0%.IPL combined with hydroquinone cream treatment group was significantly more effective than the treatment group(P<0.05).All treatment patients did not present with tissue damage,pigmentation and other adverse reactions.Conclusions IPL combined with hydroquinone cream is a safe and effective treatment of melasma,and patients get a higher rate of satisfaction.

关 键 词：黄褐斑 强脉冲光治疗 妇女 氢醍乳膏 

分 类 号：R62[医药卫生—整形外科] R758.42[医药卫生—外科学]