注射用阿奇霉素致支气管肺炎患儿突发性聋  

Sudden deafness caused by azithromycin for injection in a boy with bronchopneumonia

作　　者：徐磊[1] 王军慧 赵莉[1] 刘飞宇[1] 张雷[1] 王颖琳[1] 孙海燕[1] Xu Lei;Wang Junhui;Zhao Li;Liu Feiyu;Zhang Lei;Wang Yinglin;Sun Haiyan(Department of Pharmacy, Yantai Yuhuangding Hospital, Shandong Province, Yantai 264001, China)

机构地区：[1]烟台毓璜顶医院药学部,264001

出　　处：《药物不良反应杂志》2019年第2期140-141,共2页Adverse Drug Reactions Journal

摘　　要：1例11岁男性患儿因支气管肺炎给予注射用阿奇霉素(0.5 g静脉滴注、1次/d,每次滴注3 h)和注射用头孢替安(1.0 g静脉滴注、3次/d)抗感染。用药前患儿未诉听力异常。第1、2次静脉滴注阿奇霉素约2 h患者出现耳鸣,分别持续约2、3 h后消失,第2次用药后出现听力下降(纯音测听示右、左耳平均听阈分别为43、47 dB),诊断为感音神经性耳聋。第3次静脉滴注阿奇霉素1 h后患者出现耳鸣且持续存在,听力进一步下降(右、左耳平均听阈分别为51和60 dB)。停用阿奇霉素,继续使用头孢替安,给予银杏叶提取物片口服,(1片、2次/d)。停用阿奇霉素第2天,患儿耳鸣好转;第5天,耳鸣消失,听力好转(右、左耳平均听阈分别为42、49 dB);第40天,听力进一步好转(右、左耳平均听阈分别为32、36 dB)。An 11-year-old boy received IV infusions of azithromycin for injection 0.5 g for 3 hours once daily and cefotiam for injection 1.0 g thrice daily for bronchopneumonia. The boy did not complain of hearing abnormality before medication. Tinnitus appeared about 2 hours after the beginning of the first and second IV infusions of azithromycin and disappeared about 2 and 3 hours later, respectively. Additionally, his hearing decreased after the second dose of azithromycin (the pure-tone audiometry showed that the average hearing thresholds of his right and left ears were 43 and 47 dB, respectively). Sensorineural deafness was diagnosed. The boy developed persistent tinnitus and further hearing loss 1 hour after the beginning of the third IV infusion of azithromycin (the average hearing thresholds of the right and left ears were 51 and 60 dB, respectively). Azithromycin was discontinued, cefotiam was continued, and extract of ginkgo biloba leaves tablets were given orally (1 tablet twice daily). On day 2 after azithromycin discontinuation, his tinnitus improved. On day 5, his tinnitus disappeared and hearing improved (the average hearing thresholds of the right and left ears were 42 and 49 dB, respectively). On day 40, his hearing improved further (the average hearing thresholds of his right and left ears were 32 and 36 dB, respectively).

关 键 词：聋 听觉丧失 突发性 大环内酯类 儿童 阿奇霉素 

分 类 号：R725.6[医药卫生—儿科] R764.43[医药卫生—临床医学]