血清瘦素与酒精依赖患者认知功能的关系  

Relationship between serum leptin levels and the cognitive functions of alcohol dependent patients

作　　者：王怀志[1] 胡建[1] Wang Huaizhi;Hu Jian(Department of Psychiatry, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China)

机构地区：[1]哈尔滨医科大学附属第一医院精神科,150001

出　　处：《神经疾病与精神卫生》2019年第2期130-133,共4页Journal of Neuroscience and Mental Health

基　　金：国家自然科学基金面上项目(81271471).

摘　　要：目的研究酒精依赖患者与健康对照者的血清瘦素水平的差异,以及酒精依赖患者血清瘦素浓度与认知功能的关系。方法采取简单随机抽样,纳入45例来自中国北方符合DSM-Ⅳ中酒精依赖诊断标准的汉族男性住院患者,选取45名与酒精依赖患者组在一般资料方面相当的健康男性志愿者作为对照组,酶联免疫吸附试验检测两组受试者血清瘦素水平,应用威斯康星卡片分类测验(WCST)评定其认知功能。结果酒精依赖患者血清瘦素水平高于对照组(P<0.001);酒精依赖患者血清瘦素水平与WCST中的总错误分类数(r=0.339,P=0.023)和持续错误分类数(r=0.372,P=0.012)呈正相关,而与正确分类数(r=-0.339,P=0.023)和完成分类数(r=-0.327,P=0.029)呈负相关。结论酒精依赖患者血清瘦素水平高于正常,瘦素水平越高其认知功能损害越重。Objectives To study the difference of serum leptin levels between alcohol dependent patients and the control group, and the relationship between serum leptin levels and the cognitive functions of alcohol dependent patients. Methods A total of 45 Han male patients from Northern China with the diagnosis of alcohol dependence based on the Diagnostic and Statistical Manual of Mental Disorders( DSM-Ⅳ) were randomly selected. A total of 45 male healthy individuals were selected as the control group. Blood samples were collected from both groups, and the serum leptin levels were measured using enzyme-linked immunosorbent test. The cognitive functions were evaluated by Wisconsin Card Sorting Test( WCST). Results The level of serum leptin in the experimental group was higher than that in the control group, and the difference has statistical significance( P<0.001). In the experimental group, the level of serum leptin was positively related to the total errors( r=0.339,P=0.023) and the continuous errors( r=0.372,P=0.012) of WCST while negatively related to the total corrects( r=-0.339,P=0.023) and continuous corrects( r=-0.327,P=0.029). Conclusions The level of serum leptin in alcohol dependent patients is significantly higher than general population, and the higher the level of serum leptin is, the more severe the cognitive impairment becomes.

关 键 词：酒精依赖 瘦素 认知功能 

分 类 号：R512.6[医药卫生—内科学]