A Stepwise Annulation for the Transformation of Cyclic Ketones to Fused 6 and 7-Membered Cyclic Enimines and Enones  

作　　者：Dong-Ping Wu Qian He Dong-Huang Chen Jian-Liang Ye Pei-Qiang Huang 

机构地区：[1]Department of Chemistry,Fujian Provincial Key Laboratory of Chemical Biology,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen,Fujian 361005,China

出　　处：《Chinese Journal of Chemistry》2019年第4期315-322,I0002,共9页中国化学（英文版）

基　　金：the National Natural Science Foundation of China(Nos.21672176 and 21332007);the National Key R&D Program of China(grant No.2017YFA0207302);the Program for Changjiang Scholars and Innovative Research Team in University(PCSIRT)of Ministry of Education.

摘　　要：The efficient construction of functionalized polycyclic structures is an imports nt objective in organic synthesis.Herein,we disclose a three-step"[2+n]"annulation method for the transformation of cyclic ketones to fused enimines and enones.The method relies on the Suzuki coupling reaction and the amide reductive alkenylation reaction.A series of fused bicyclic(6/6,6/7,8/7)and tricyclic(6/6/6;6/6/7,6/5/7)ring systems bearing an α,β-enimine or an α,β-enone functionality have been synthetized in good overall yields.

关 键 词：CYCLIC KETONES FUSED 6 and 7-Membered CYCLIC Enimines and ENONES functionalized POLYCYCLIC structures 

分 类 号：O6[理学—化学]