加味二仙汤结合运动对绝经后骨质疏松症疗效观察  

Clinical Observation on Modified ErXian Decoction Joined with Exercise in Treating Postmenopausal Osteoporosis

作　　者：张帆[1] 王玉珠[2] ZHANG Fan;WANG Yuzhu(Gansu University of Chinese Medicine, Lanzhou 730000, China;Gansu Provincial Hospital of Traditional Chinese Medicine)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃省中医院

出　　处：《西部中医药》2019年第3期99-102,共4页Western Journal of Traditional Chinese Medicine

摘　　要：目的:探讨加味二仙汤结合运动对绝经后骨质疏松患者骨密度、骨代谢标志物及视觉模拟评分(visual analogue scale,VAS)的影响。方法:将绝经后骨质疏松肾虚血瘀型患者60例随机分为治疗组、对照组各30例,2组患者均以钙尔奇D(600 mg/d)作为基础药联合运动指导干预,治疗组在此基础上应用加味二仙汤治疗。治疗3个月后应用超声X线骨密度仪检测桡骨远端骨密度(BMD)、25羟基维生素D[25(OH)D]、Ⅰ型胶原羧基端肽β特殊序列(β-CTX)的浓度并观察VAS评分。结果:1)与治疗前相比,治疗组VAS评分下降(P<0.05);对照组VAS评分有一定程度降低,但差异无统计学意义(P>0.05)。2)2组BMD浓度治疗前后比较差异无统计学意义(P>0.05)。3)2组β-CTX治疗前后比较差异无统计学意义(P>0.05),2组25(OH)D治疗后升高(P<0.05),治疗后2组VAS评分、25(OH)D比较差异有统计学意义(P<0.05),BMD、β-CTX比较差异无统计学意义(P>0.05)。结论:加味二仙汤结合钙尔奇D及运动能够改善绝经后骨质疏松症肾虚血瘀血型患者临床症状,机制可能与降低β-CTX浓度,提高25(OH)D水平有关。Objective: To discuss the effects of modified ErXian decoction combined with exercise on VAS, bone metabolic markers and bone density of the patients suffering postmenopausal osteoporosis (PMOP). Methods: Sixty patients of PMOP of kidney deficiency and blood stasis pattern were randomized into the treatment group and the control group, 30 cases each group, both groups were intervened by CaltrateD (600mg each day) as the basic medicine and sports guidance, the treatment group were treated by modified ErXian decoction. After treating for three months, ultrasonic X-ray bone mineral density instrument was used to detect bone density (BMD) of distal radius, the concentrations of 25 (OH)D and β-CTX, and to observe VAS scores. Results: 1) Compared with before treating, VAS scores of the treatment group decreased, VAS scores of the control group lowered to a certain degree, while the difference had no statistical meaning (P>0.05). 2) The difference had no statistical meaning in the comparisons of the concentrations of BMD between both groups before and after treating (P>0.05). 3) The difference showed no statistical meaning in the comparisons of β-CTX between both groups before and after treating (P>0.05), the levels of 25 (OH)D rose in both groups after treating (P<0.05), the difference could be found in the comparisons of VAS scores and 25 (OH)D between both groups after treating (P<0.05), the difference had no statistical meaning in the comparisons of BMD and β-CTX (P>0.05). Conclusion: Modified ErXian decoction, Caltrate D and exercise could improve clinical symptoms of PMOP patients, and the mechanism might be related to lowering the concentrations of β-CTX and increasing the level of 25(OH)D.

关 键 词：绝经后骨质疏松症 骨代谢标志物 加味二仙汤 

分 类 号：R274[医药卫生—中医骨伤科学]