济南地区孕妇以及健康献血者戊型肝炎病毒感染的研究  

Hepatitis E virus infection in pregnant women and blood donors in Jinan

作　　者：张文静[1] 康佩佩[1] 叶辉[1] 王玉霞[1] 庄云龙[1] Zhang Wenjing;Kang Peipei;Ye Hui;Wang Yuxia;Zhuang Yunlong(Institute of Hematology, Blood Center of Shandong Province, Jinan, 250014, China)

机构地区：[1]山东省血液中心血液研究所,济南250014

出　　处：《中华实验和临床病毒学杂志》2019年第2期175-177,共3页Chinese Journal of Experimental and Clinical Virology

基　　金：山东省自然科学基金(ZR2017MH070);山东省医药卫生科技发展计划项目(2017WS181);山东省血液中心资助项目(201701).

摘　　要：目的调查对济南地区孕妇及健康献血者戊型肝炎病毒(hepatitis E virus, HEV)的感染状况。方法收集2015年6月份至2016年10月份于本中心进行新生儿溶血产前筛查的孕妇血浆共651例、同期献血者血样600例进行酶联免疫吸附试验(ELISA),筛查抗HEV IgG、IgM抗体。结果651例孕妇血样本中,检出HEV-IgG阳性17例(17/651,2.61%),未检出HEV-IgM阳性;600例献血者血样本中,检出HEV-IgG阳性98例(98/600,16.33%)、HEV-IgM阳性5例(5/600,0.83%);两组HEV-IgG感染率具有显著性差异(χ^2=70.43,P<0.0001)。结论济南地区孕妇群体中HEV感染率显著低于献血者人群的感染率,但鉴于孕妇HEV感染的病死率较高,孕产期HEV感染仍不容忽视。济南地区献血者中HEV感染率较高,临床输血仍存在风险,在今后的输血保障工作中应引起重视。Objective To study the hepatitis E virus(HEV) infection in pregnant women and the healthy blood donors in Jinan. Methods A total of 651 blood samples from pregnant women who came for screening of hemolytic disease of newborn and 600 blood samples from blood donors were collected during June 2015 to October 2016. All the blood samples were tested for anti-HEV IgG and anti-HEV IgM antibodies by using enzyme-linked immunosorbent assay (ELISA). Results Anti-HEV IgG was positive in 2.61%(17/651) of the blood samples from the pregnant women, and none of the samples were positive for anti-HEV IgM. The serum positive rates for anti-HEV IgG and IgM in blood donors were 16.33%(98/600) and 0.83%(5/600) respectively. The seroprevalence of the two groups was significantly different(χ^2=70.43, P<0.0001). Conclusions The HEV infection rate in pregnant women was much lower compared with that in blood donors in Jinan;however, in view of the high mortality of HEV infection in pregnant women, it still cannot be neglected. The infection of HEV in blood donors of Jinan was confirmed, suggesting the potential risk of transfusion-transmitted HEV infection.

关 键 词：戊型肝炎病毒 孕妇 献血者 IgG IGM 

分 类 号：R512.6[医药卫生—内科学] R446.6[医药卫生—临床医学]