甲亢患者用药临床科普干预及效果评价  

Clinical science intervention and effect evaluation of hyperthyroidism patients

作　　者：蒋俊杰[1] 张静[1] 聂松柳[1] 王欣 沈炳香[1] 刘荣莉[2] 屠家启[1] 张晓艳 陈捷 黄新民 JIANG Jun-jie;ZHANG Jing;NIE Song-liu;WANG Xin;SHEN Bing-xiang;LIU Rong-li;TU Jia-qi;ZHANG Xiao-yan;CHEN Jie;HUANG Xin-min(Department of Pharmacy,Liuan People's Hospital,Anhui Liuan 237005,China;Department of Endocrinology,Liuan People's Hospital,Anhui Liuan 237005,China;Department of Laboratory,Liuan People's Hospital,Anhui Liuan 237005,China)

机构地区：[1]六安市人民医院药学部,安徽六安237005 [2]六安市人民医院内分泌科,安徽六安237005 [3]六安市人民医院检验科,安徽六安237005

出　　处：《临床药物治疗杂志》2019年第3期64-68,共5页Clinical Medication Journal

基　　金：全国医药经济信息网科技传播创新工程2017年重点项目立项名单(第一批)(CMEI2017KP00201)

摘　　要：目的:探讨用药临床科普干预在门诊甲状腺功能亢进患者中的应用效果。方法:以2017年6月至2018年8月六安市人民医院收治的200例确诊为甲亢的患者作为研究对象,在甲亢患者初次就诊时按随机数字法分为对照组和观察组,每组患者100例。对照组患者予以常规健康宣教,观察组在对照组基础上对患者实施个体化的甲亢用药临床科普干预。比较2组患者治疗前后(复诊时间为治疗的第1、2、3、6、9和12个月),甲亢症状的缓解情况、血清T_3、T_4、FT_3、FT_4和TSH水平变化,及在治疗过程中药物不良反应发生率。结果:观察组患者在科普干预后用药依从性明显提高,第1次和第2次量表平均得分分别为4.56和6. 11分,差异有统计学意义(P<0.05); 2组患者血清T_3、T_4、FT_3、FT_4第1次就诊指标无显著差异,在第6次复诊指标均下降,且观察组下降更明显,与对照组比较,差异有统计学意义(P<0.05);评估用药科普干预后甲亢诊断指数及甲亢Gravas眼病分级改善情况,观察组在对患者症状改善方面高于对照组,差异有统计学意义(P<0.05)。在甲亢药物不良反应发生率方面,观察组发生率更低。结论:甲状腺功能亢进的药物治疗疗程较长,坚持疗程,规范治疗是治愈的保障。对甲亢患者的临床用药科普教育和干预,可提高患者用药依从性,能促进甲状腺功能亢进患者规范治疗,保证药物疗效,降低药物不良反应的发生率,提升治疗效果,并以积极的心态坚持完成疗程。Objective: To explore the application effect of clinical popular science intervention in patients with hyperthyroidism in outpatients. Methods: 200 patients diagnosed with hyperthyroidism admitted from June 2017 to August 2018 were randomly divided into the control group and the observation group. The control group received routine health education, and the observation group was given an individualized hyperthyroidism medication clinical science intervention based on routine health education comparison of the two groups of patients before and after treatment(review time is 1, 2, 3, 6, 9 and 12 months of treatment), the relief of hyperthyroid symptoms, serum T3, T4, FT3, FT4 and TSH levels, and the incidence of adverse drug reactions during the treatment process. Results : There were no significant differences in the basic conditions of the patients between the two groups, such as gender, age, and income of the residents. In the observation group, the medication compliance was significantly improved after the intervention of the science, and the average scores of the first and second scales were 4. 56 and 6. 11, respectively. The difference was statistically significant(P <0. 05);there were no significant differences in the first visits of serum T3, T4, FT3 and FT4 between the two groups. The scores of the 6th follow-up were lower, and the decline was more obvious in the observation group, which was statistically significant compared with the control group. To evaluate the improvement of the hyperthyroidism diagnosis index and the Gravas eye disease classification after the intervention of the medical science, the improvement of the symptoms in the observation group was higher than that of the control group(P < 0. 05).In the incidence of adverse drug reactions to hyperthyroidism, the incidence of the observation group was lower. Conclusion: The drug treatment of hyperthyroidism is longer, adhere to the course of treatment, standard treatment is the guarantee of cure, and the clinical drug education and interventio

关 键 词：甲亢 用药科普 干预 效果 研究 

分 类 号：R977.14[医药卫生—药品] R969.3[医药卫生—药学]