高血压患者胱硫醚-β-合酶、硫化氢与颈动脉内膜中膜厚度的关系  

The correlation between cystathionine-β-synthase, hydrogen sulfide levels and carotid intima-media thickness in patients with hypertension

作　　者：覃咏梅 林玲[2] 王延博 王蓓[2] 冯岚[3] 周莲[4] QIN Yongmei;LIN Ling;WANG Yanbo;WANG Bei;FENG Lan;ZHOU Lian(Graduate Studies of Guangzhou Medical University, Guangzhou, Guangdong 511400, China)

机构地区：[1]广州医科大学研究生院,广东省广州市511400 [2]海南省第三人民医院心血管内科,海南省三亚市572000 [3]海南省第三人民医院功能科,海南省三亚市572000 [4]海南省第三人民医院检验科,海南省三亚市572000

出　　处：《中国动脉硬化杂志》2019年第5期417-420,共4页Chinese Journal of Arteriosclerosis

基　　金：海南省自然科学基金(20168343);三亚市医疗卫生科技创新项目(2015YW20)

摘　　要：目的探讨高血压患者血清胱硫醚-β-合酶(CBS)、硫化氢(H_2S)水平与颈动脉内膜中膜厚度(CIMT)的相关性。方法对116例高血压患者,测量其血压、同型半胱氨酸(Hcy)、血脂四项(总胆固醇、低密度脂蛋白胆固醇、甘油三酯、高密度脂蛋白胆固醇),并检测CBS、H_2S水平和CIMT。依据Hcy水平将高血压患者分为H型高血压组(Hcy≥10μmol/L)和非H型高血压组(Hcy<10μmol/L),比较两组Hcy、血脂、CBS、H_2S、CIMT的差异。采用Pearson法分析各指标与CIMT之间的相关性。结果 H型高血压组患者CIMT高于非H型高血压组(P<0.05),CBS、H_2S水平均低于非H型高血压组(均P<0.05)。相关性分析结果显示:在高血压患者中,Hcy与CIMT呈正相关(r=0.752,P<0.05);CBS、H_2S与Hcy呈负相关(r分别为-0.413、-0.698,均P<0.05),与CIMT呈负相关(r分别为-0.518、-0.779,均P<0.05)。结论与非H型高血压患者相比,H型高血压患者颈动脉粥样硬化程度更明显。高血压患者的CBS、H_2S与颈动脉粥样硬化密切相关,有望作为高血压患者动脉粥样硬化的早期预测指标。Aim To investigate the correlation between serum cystathionine-β-synthase(CBS), hydrogen sulfide (H2S) levels and carotid intima-media thickness (CIMT) in patients with hypertension. Methods Between October 2017 and March 2018, a total of 116 patients with essential hypertension were enrolled from in-patient department of our hospital. The blood pressure, homocysteine (Hcy), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDLC) and low density lipoprotein cholesterol (LDLC) were measured in all selected hypertensive patients.At the same time, the levels of CIMT, CBS and H2S were detected. According to the levels of Hcy, the patients with hypertension were divided into two groups:H hypertension group (Hcy≥10 μmol/L) and non H hypertension group (Hcy<10 μmol/L), and the differences of Hcy, blood lipids, CBS, H2S and CIMT were compared. The correlation between the indexes and CIMT was analyzed by Pearson test. Results The CIMT of H hypertension group was higher than that of non H hypertension group (P<0.05), and the levels of H2S and CBS in H hypertension group were lower than that in non H hypertension group (P<0.05). Correlation analysis showed that Hcy was positively correlated with CIMT in hypertensive patients (r=0.752, P<0.05). CBS and H2S were negatively correlated with Hcy (r =-0.413,-0.698, P<0.05) and with CIMT (r=-0.518,-0.779, P<0.05). Conclusions Compared with non H hypertensive patients, the degree of carotid atherosclerosis is more pronounced in patients with H hypertension. In patients with hypertension, the levels of CBS and H2S are closely related with carotid atherosclerosis, which is expected to be an early predictor of atherosclerosis in hypertensive patients.

关 键 词：高血压 同型半胱氨酸 胱硫醚-β-合酶 硫化氢 颈动脉内膜中膜厚度 动脉粥样硬化 

分 类 号：R5[医药卫生—内科学]