模拟失重条件下Wnt/β-catenin信号通路调节成骨细胞功能的研究进展  

Advances in Wnt/β-catenin signaling pathway regulating osteoblast functions under simulated microgravity

作　　者：张丽君 王可 王艺璇 胡泽兵 李高志 石菲 曹新生 张舒 ZHANG Lijun;WANG Ke;WANG Yixuan;HU Zebing;LI Gaozhi;SHI Fei;CAO Xinsheng;ZHANG Shu(Department of Aerospace Biodynamics,Medical University of Air Force,The Key Laboratory of Aerospace Medicine,Chinese Ministry of Education,Xi’an 710032,Shaanxi Province,China)

机构地区：[1]空军军医大学航空航天生物动力学教研室航空航天医学教育部重点实验室,陕西西安710032

出　　处：《解放军医学院学报》2019年第3期290-292,297,共4页Academic Journal of Chinese PLA Medical School

基　　金：国家自然科学基金项目(31570939;81701856;81471815;31170889);中国载人航天预研项目(020106)~~

摘　　要：Wnt/β-catenin信号通路在成骨细胞分化早期发挥促进作用,分化末期发挥抑制作用,并且在失重环境下调节成骨细胞的发育,参与失重导致的骨丢失调控,表现为在失重条件下,成骨细胞的Wnt/β-catenin信号通路的激活受抑,进而影响了成骨细胞的增殖分化。本文就Wnt/β-catenin信号通路调控成骨细胞的发育及其在失重条件下对成骨细胞功能影响的研究进展做以下综述。Wnt/β-catenin signaling pathway plays an important role in the differentiation and proliferation of osteoblasts.Activation of Wnt/β-catenin signaling pathway promotes the differentiation of osteoblast in the early stage of differentiation while inhibits it at the end of differentiation.It also regulates the development of osteoblasts under microgravity and is involved in bone loss induced by microgravity.It has shown that the activation of Wnt/β-catenin signaling pathway in osteoblasts is inhibited under microgravity,which affects the proliferation and differentiation of osteoblasts.The progresses related to the effects of Wnt/β-catenin signaling pathway on the development and the function of osteoblasts under microgravity are reviewed in this article.

关 键 词：WNT/Β-CATENIN信号通路 成骨细胞 失重 

分 类 号：R852.22[医药卫生—航空、航天与航海医学]