真人养脏汤治疗溃疡性结肠炎的临床疗效及其对疾病活动指数评分和血清炎症因子的影响  

Clinical efficacy of Dongbin organ-nourishing decoction in ulcerative colitis patients regarding disease activity and serum inflammatory cytokines

作　　者：韩莹[1] 张岩[2] 杨德芳 张春蕾[1] 王兴淼 赵晶[1] 季顺欣[1] HAN Ying;ZHANG Yan;YANG De-fang(Maternal and Child Health Education Department,Heilongjiang University of Traditional Chinese Medicine Heilongjiang Jiamusi College,Jiamusi Heilongjiang 154000,China;Department of Anesthesiology,Jiamusi University Affiliated Second Hospital,Jiamusi Heilongjiang 154000,China.)

机构地区：[1]黑龙江中医药大学黑龙江中医药大学佳木斯学院妇幼保健教研室,黑龙江佳木斯154000 [2]佳木斯大学附属第二医院口腔医院麻醉科,黑龙江佳木斯154000

出　　处：《临床和实验医学杂志》2019年第9期936-939,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的观察真人养脏汤对溃疡性结肠炎患者临床疗效,及其对疾病活动指数评分及血清炎症因子白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平的影响。方法前瞻性选择佳木斯大学附属第二医院收治的63例轻、中度活动期溃疡性结肠炎且中医辨证属脾肾阳虚证的患者,按照数字单双号分为分为观察组(n=32)和对照组(n=31)。观察组以真人养脏汤加减治疗,对照组以美沙拉嗪肠溶片治疗,疗程均为6周。比较治疗前后两组中医证候评分及结肠黏膜病变活动指数(Sutherland疾病活动指数)评分,判定临床疗效。比较治疗前后两组血清IL-6、IL-8、TNF-α水平的变化。结果与治疗前比较,两组患者治疗后腹泻、腹痛、黏液脓血便、里急后重证候评分均显著降低(P <0. 05);观察组患者上述证候评分均明显低于对照组(P <0. 05)。与治疗前比较,两组患者治疗后Sutherland疾病活动指数评分均显著降低(P <0. 05);观察组Sutherland疾病活动指数评分显著低于对照组(P <0. 05)。观察组临床总有效率显著高于对照组(P <0. 05)。与治疗前比较,两组患者治疗后血清IL-6、IL-8、TNF-α水平均显著降低(P <0. 05);观察组血清IL-6、IL-8、TNF-α水平均显著低于对照组(P <0. 05);在治疗过程中,两组患者均未发生严重不良反应。结论真人养脏汤对溃疡性结肠炎患者的临床疗效显著,显著降低血清IL-6、IL-8、TNF-α水平,安全性较好,值得临床推广应用。Objective To observe clinical efficacy of Dongbin organ-nourishing decoction in ulcerative colitis patients regarding disease activity index score and inflammatory cytokines such as interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)in patients with ulcerative colitis.Methods 63 patients with mild or moderate active ulcerative colitis and splenonephro-yang asthenia syndrome were divided into observation group(n=32)(with Dongbin organ-nourishing decoction)and control group(n=31)(with mesalazine enteric-coated tablets).Treatment for both groups lasted for 6 weeks.Before and after treatment,traditional Chinese medicine syndrome scores,colonic mucosal activity indexes(Sutherland disease activity indexes)and IL-6,IL-8,TNF-αlevels were compared to study clinical efficacy.Results After treatment,symptom scores of diarrhea,abdominal pain,mucopurulent and bloody stool,and tenesmus of both groups decreased compared with baseline(P<0.05),with observation group decreasing more remarkable compared with control group(P<0.05).After treatment,Sutherland disease activity indexes of both groups decreased compared with baseline(P<0.05),with observation group decreasing more remarkable compared with control group(P<0.05).The total clinical efficiency of observation group was significantly higher than that of the control group(P<0.05).After treatment,IL-6,IL-8,TNF-αlevels of both groups decreased compared with baseline(P<0.05),with observation group decreasing more remarkable compared with control group(P<0.05).The two groups had no serious complications.Conclusion Clinical efficacy of Dongbin organ-nourishing decoction in treating patients with ulcerative colitis was significant with remarkably decreased levels of serum IL-6,IL-8 and TNF-α,implicating safe and rosy clinical application.

关 键 词：溃疡性结肠炎 真人养脏汤 白细胞介素-6 白细胞介素-8 肿瘤坏死因子-α 

分 类 号：R259[医药卫生—中西医结合]