静息态功能磁共振成像比率低频振幅变化在急性脑干梗死脑神经功能损伤中的价值分析  

Value of fractional amplitude of low-frequency fluctuation ofresting-state functional magnetic resonance imaging in neurological impairment in patients with acute brain stem infarction

作　　者：王丽[1] 张志[1] 吴超然[2] WANG Li;ZHANG Zhi;WU Chaoran(Department of Radiology,The First Affiliated Hospital of Chengdu Medical College,Chengdu,Sichuan 610500,China;West China Hospital of Sichuan University,Chengdu,Sichuan 610065,China)

机构地区：[1]成都医学院第一附属医院放射科,四川成都610500 [2]四川大学华西医院,四川成都610065

出　　处：《安徽医药》2019年第6期1095-1097,共3页Anhui Medical and Pharmaceutical Journal

基　　金：国家自然科学基金项目(81471141)

摘　　要：目的分析静息态功能磁共振成像(fMRI)比率低频振幅(fALFF)变化在急性脑干梗死脑神经功能损伤及预后判断中的价值。方法选取成都医学院第一附属医院2016年7月至2017年5月收治的30例急性脑干梗死病人为观察组,同期选取在成都医学院第一附属医院体检结果无异常的30例志愿者为对照组。采集两组fMRI资料,分析两组fALFF值对大脑各个区域的活动情况,然后进行组间比较。结果与对照组比较,观察组急性脑干梗死后,在双侧楔前叶、双侧顶下小叶、双侧扣带回、小脑后叶以及右侧海马上的fALFF值均表现为减弱信号(t=-5.239、-5.894、-4.761、-10.682、-4.528、-6.948、-5.318、-4.963,均P<0.001),在双侧中央前回、左侧丘脑、额上回以及左尾状核上的fALFF值均表现为增强信号(t=5.602、4.982、11.327、6.283、5.309、4.668,均P<0.001)。结论病人在急性脑干梗死后,fALFF值会出现异常,fALFF值的变化对急性脑干梗死发病后的脑功能受损情况及预后的判断有一定的参考意义。Objective To analyze the value of fractional amplitude of low-frequency fluctuation(fALFF)of resting-state functional magnetic resonance imaging(fMRI)in neurological impairment of patients with acute brain stem infarction.Methods Thirty patients with acute brain stem infarction admitted to The First Affiliated Hospital of Chengdu Medical College from July 2016 to May 2017 were enrolled as the research group,and 30 volunteers who had no abnormal results of health examination in The First Affiliated Hospital of Chengdu Medical College during the same period were selected as controls(normal group).FMRI data of the two groups of subjects were collected.The fALFF values in different regions of the brain were analyzed and compared between the two groups.Results Compared with the control group,the fALFF values in the bilateral anterior lobe,the inferior parietal lobule,the bilateral cingulate gyrus,the posterior cerebellar lobe and the right hippocampus of the research group showed weakened signals after acute brain stem infarction(t=-5.239,-5.894,-4.761,-10.682,-4.528,-6.948,-5.318,and-4.963,respectively,all P<0.001).Compared with the control group,the fALFF values in the bilateral precentral gyrus,left thalamus,superior frontal gyrus and left caudate nucleus of the research group showed enhanced signals after acute brain stem infarction(t=5.602,4.982,11.327,6.283,5.309,and 4.668,respectively,all P<0.001).Conclusion In patients with acute brain stem infarction,the fractional amplitude of low-frequency fluctuation of functional magnetic resonance imaging will appear abnormal,which has a certain reference value for judging the impairment of brain function and prognosis of the patients.

关 键 词：静息态功能磁共振成像 急性脑干梗死 比率低频振幅 脑损伤 

分 类 号：R445.2[医药卫生—影像医学与核医学]