轻中度H型高血压应用苯磺酸氨氯地平联合叶酸的治疗效果及对血压与血浆Hcy水平的影响  

Therapeutic effect of amlodipine besylate combined with folic acid in mild to moderate H-type hypertension and its effect on blood pressure and plasma Hcy levels

作　　者：黄流强 黄江南 石春光 李龙 HUANG Liu-qiang;HUANG Jiang-nan;SHI Chun-guang;LI Long(Wuming Hospital Affiliated to Guangxi Medical University,Guangxi Nanning 530199,China)

机构地区：[1]广西医科大学附属武鸣医院,广西南宁530199

出　　处：《中西医结合心血管病电子杂志》2019年第12期10-13,共4页Cardiovascular Disease Electronic Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的探讨苯磺酸氨氯地平联合叶酸在轻中度H型高血压患者中的治疗效果及对血压水平与血浆同型半胱氨酸(Hcy)水平的影响。方法选取2016年5月～2018年5月入院治疗的轻中度H型高血压患者240例,根据治疗药物分为对照组(n=120例)和观察组(n=120例)。对照组采用苯磺酸氨氯地平治疗,观察组在对照组基础上联合叶酸治疗,两组均连续治疗3个月,治疗完毕后对患者效果进行评估。采用血压计测定两组治疗前、治疗后3个月舒张压、收缩压水平;采用循环酶法测定两组Hcy水平;采用酶联免疫吸附试验测定两组治疗前、治疗后3个月C反应蛋白(CRP)、白细胞介素-6(IL-6)和肿瘤坏死因子-a(TNF-a)水平;记录并统计两组治疗后3个月恶心呕吐、腹泻、皮疹、过敏发生率,比较两组临床治疗效果及对血压、血浆Hcy水平的影响。结果观察组与对照组治疗后3个月SDP、DBP和Hcy水平,均低于治疗前,差异有统计学意义(P<0.05);观察组治疗后3个月SDP、DBP和Hcy水平,均低于对照组,差异有统计学意义(P<0.05);观察组与对照组治疗后3个月CRP、IL-6及TNF-a水平,均低于治疗前,差异有统计学意义(P<0.05);观察组治疗后3个月CRP、IL-6及TNF-a水平,均低于对照组,差异有统计学意义(P<0.05);观察组苯磺酸氨氯地平片联合叶酸治疗后3个月恶心呕吐、腹泻、皮疹、过敏发生率与对照组比较,差异无统计学意义(P>0.05)。结论将苯磺酸氨氯地平片联合叶酸用于轻中度H型高血压患者有助于改善患者血压水平,降低炎症因子水平,药物安全性较高,值得推广应用。Objective To investigate the therapeutic effect of amlodipine besylate combined with folic acid in patients with mild to moderate H-type hypertension and its effect on blood pressure level and plasma homocysteine (Hcy) level.Methods A total of 240 mild to moderate H-type hypertensive patients who were admitted to hospital from May 2016 to May 2018 were selected and divided into a control group (n=120) and an observation group (n=120) according to the therapeutic drugs.The control group was treated with amlodipine besylate and the observation group was treated with folic acid on the basis of the control group. Both groups were treated for 3 months consecutively.After the treatment was completed,the effect of the patient was evaluated.Sphygmomanometer was used to measure diastolic blood pressure and systolic blood pressure before treatment and 3 months after treatment.Cyclic enzymatic method was used to measure the levels of Hcy in both groups;enzyme-linked immunosorbent assay was used to measure C response before and after treatment in both groups.Protein (CRP),Interleukin-6 (IL-6),and Tumor Necrosis Factor-a (TNF-a) levels;The incidence of nausea and vomiting,diarrhea,rash,and allergy 3 months after treatment in both groups was recorded and compared. Two groups of clinical treatment effects and blood pressure,plasma Hcy levels.Results The SDP,DBP and Hcy levels in the observation group and the control group were lower than those before treatment (P<0.05) 3 months after treatment. The SDP,DBP and Hcy levels in the observation group 3 months after treatment were lower than those in the control group (P<0.05);The levels of CRP,IL-6 and TNF-a in the observation group and the control group at 3 months after treatment were all lower than before treatment (P<0.05);CRP and IL-6 were observed in the observation group at 3 months after treatment.The level of TNF-a was lower than that of the control group (P<0.05);there was no statistical difference in the incidence of nausea,vomiting,diarrhea,rash,and allergy 3 months afte

关 键 词：苯磺酸氨氯地平片 叶酸 轻中度H型高血压 血压水平 炎症因子 安全性 

分 类 号：R544.1[医药卫生—心血管疾病]