左氧氟沙星联合中药治疗慢性前列腺炎的疗效及对患者免疫功能的影响  

The effects of levofloxacin combined with traditional Chinese medicine on chronic prostatitis and its influence on immune function

作　　者：应俊辉[1] 周长春[1] 金亿里[1] 孙鹏[2] 卢大乔[1] Ying Junhui;Zhou Changchun;Jin Yili;Sun Peng;Lu Daqiao(Department of Urology,Dongyang Hospital Affiliated to Wenzhou Medical University,Dongyang 322100,China)

机构地区：[1]温州医学院附属东阳市人民医院泌尿外科,东阳322100 [2]浙江金华市中心医院泌尿外科

出　　处：《中国临床保健杂志》2019年第3期356-358,共3页Chinese Journal of Clinical Healthcare

基　　金：浙江省医药卫生一般研究计划项目(2016KYB255)

摘　　要：目的探讨左氧氟沙星联合中药治疗慢性前列腺炎的疗效及对患者免疫功能的影响。方法采用随机数字表法将84例慢性前列腺炎患者纳入对照组与观察组,每组都为42例。对照组应用左氧氟沙星治疗,观察组应用左氧氟沙星联合中药治疗,对比两组的中医证候评分、慢性前列腺炎症状指数(NIH-CPSI)评分、免疫功能指标[巨噬细胞炎性蛋白-1α(MIP-1α)、巨噬细胞炎性蛋白2(MIP-2)]、临床疗效及不良反应(恶心呕吐、腹泻、头晕、皮肤过敏)。结果观察组中医证候评分中的尿频急、尿痛、余沥不尽、阴囊潮湿、舌红苔黄、脉滑得分均低于对照组,观察组NIH-CPSI评分中的盆腔疼痛、尿路症状、生活质量、前列腺症状得分均低于对照组,观察组治疗后的前列腺液中免疫相关炎性因子MIP-1α和MIP-2浓度低于对照组,观察组的总有效率(92. 9%)高于对照组(76. 2%),各组差异均有统计学意义(P <0. 05)。结论左氧氟沙星联合中药治疗慢性前列腺炎的疗效满意,可明显改善患者的临床症状与生活质量,提高免疫功能,不良反应轻微。Objective To analyze the curative effect of levofloxacin combined with traditional Chinese medicine on chronic prostatitis and its influence on the immune function of patients.Methods 84 cases of chronic prostatitis in our hospital were randomly divided into control group and observation group,each group was 42 cases,the control group was treated with levofloxacin,the observation group was treated with levofloxacin combined with traditional Chinese medicine,and the scores of TCM syndromes of the two groups were compared.NIH-CPSI score (pelvic pain,urinary tract symptoms,quality of life,prostate symptoms),immune function index (MIP-1a and MIP-2 concentration),clinical efficacy and adverse reactions (nausea and vomiting,diarrhea,dizziness,skin allergy).Results The scores of urinary frequency,urinary pain,excess leaching,scrotal dampness,red tongue coating and yellow pulse sliding in the observation group were lower than those in the control group.The scores of pelvic pain,urinary tract symptoms,quality of life and prostatic symptoms in the NIH-CPSI score in the observation group were lower than those in the control group.The concentrations of MIP-1a and MIP-2 in the prostatic fluid of the observation group were lower than those in the control group after treatment.The total effective rate of the observation group (92.9%) was higher than that of the control group (76.2 %) with significant differences among the groups (P<0.05).Conclusion Levofloxacin combined with traditional Chinese medicine in the treatment of chronic prostatitis can significantly improve the clinical symptoms,quality of life and immune function and reduce adverse reactions.

关 键 词：前列腺炎 左氧氟沙星 中草药 免疫减弱宿主 生活质量 

分 类 号：R697.33[医药卫生—泌尿科学]