N-端脑利钠肽前体水平和冠心病病变程度的相关性分析  

Analysis of correlation between N-terminal pro brain natriuretic peptide(NT-proBNP) levels and the severity of coronary heart disease

作　　者：黄爱群 李远宁[1] 钟晖[1] 万汶沁 卢艳芬 熊美 HUANG Ai-qun;LI Yuan-ning;ZHONG Hui(Humen Hospital of Dongguan City,Guangdong Province,Dongguan 523900,China)

机构地区：[1]东莞市虎门医院,广东东莞523900

出　　处：《中国处方药》2019年第5期126-127,共2页Journal of China Prescription Drug

摘　　要：目的探讨N-端脑利钠肽前体(NT-proBNP)水平和冠心病病变程度的相关性,为临床早期诊断冠心病提供参考。方法随机选取2017年7月～2018年5月于心血管内科接受冠状动脉造影术的90例住院患者作为本次研究对象,根据冠状动脉造影结果分为正常对照组28例、研究组62例,将研究组患者分为稳定性心绞痛(18例)、不稳定性心绞痛(28例)和急性心肌梗死(16例)。根据患者心功能进行分级,Ⅰ级患者5例,Ⅱ级患者24例,Ⅲ级患者26例,Ⅳ级患者7例。结果与正常对照组相比,研究组血浆N-端脑利钠肽前体水平差异有统计学意义(P <0.05),且随着疾病病程严重性程度,血清N-端脑利钠肽前体水平逐渐增高(P <0.05);不同心功能分级患者的N-端脑利钠肽前体水平均高于对照组(P<0.05);随着心功能的严重程度越严重,血清N-端脑利钠肽前体水平也随之增高,差异具有统计学意义(P <0.05)。结论冠心病患者较健康正常人血清N-端脑利钠肽前体浓度明显升高,且升高的程度与冠状动脉的病变程度密切相关,可将其作为冠心病患者的诊断指标之一,并有助于判断其冠心病病变程度。Objective To investigate correlation of the N-terminal pro brain natriuretic peptide(NT-proBNP) level and coronary heart disease lesion degree and provide reference for clinical early diagnosis of coronary heart disease.Methods 90 cases of hospitalized patients were randomly selected from July 2017 to May 2018 in our hospital cardiovascular internal medicine to accept coronary angiography as the research objects.According to the results of coronary angiography,90 cases of hospitalized patients were divided into normal control group(28 cases) and study group(62 cases).Patients in the study group were divided into stable angina(18 cases),unstable angina(28 cases) and acute myocardial infarction(16 cases).The patients were graded according to cardiac function,5 patients with grade Ⅰ,24 patients with grade Ⅱ,26 patients with grade Ⅲ,and 7 patients with grade IV.Results Compared with normal control group,the NT-proBNP level of study group was statistically significant difference(P<0.05),and The serum level of NT-proBNP increased gradually with the severity of the disease(P<0.05);The levels of N-terminal brain natriuretic peptide precursors in patients with different degrees of coronary heart disease were higher than those in the control group(P<0.05).The more severe of cardiac function,and serum N-terminal brain natriuretic peptide precursor levels were higher,and the difference was statistically significant(P<0.05).Conclusion Compared with normal control group,the NT-proBNP of patients with coronary heart disease(CHD) increased significantly,and is closely related to the degree of coronary artery lesions,it can be as one of the diagnosis index of patients with coronary artery disease.

关 键 词：冠心病 N-端脑利钠肽前体 冠状动脉 

分 类 号：R541.4[医药卫生—心血管疾病]