1350名患儿血小板抗体检测结果分析  

Detection of platelet antibodies in 1 350 pediatric patients

作　　者：张慧敏[1] 付晓艳 马曙轩[1] 郭凯 王笑欢 汪德清 李小飞 ZHANG Huimin;FU Xiaoyan;MA Shuxuan;GUO Kai;WANG Xiaohuan;WANG Deqing;Li Xiaofei(Department of Transfusion Medicine,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045,China)

机构地区：[1]国家儿童医学中心首都医科大学附属北京儿童医院输血科,北京100045

出　　处：《中国输血杂志》2019年第2期109-110,共2页Chinese Journal of Blood Transfusion

基　　金：国家自然科学基金面上项目(81770914)

摘　　要：目的分析血小板抗体检测患儿阳性率,探讨其与血小板输注次数及其疾病相关性。方法回顾性分析本院2016年1月—2018年6月1 350例患儿血小板抗体检测结果,根据血小板抗体检测时血小板输注次数分成3组:0次组(675例)、1—3次组(384例)和>3次组(291例),分别统计分析各组血小板抗体检测阳性发生率,并分析抗体阳性患儿的疾病分布情况。结果 1 350例患儿共检出血小板抗体阳性162例(12%)。0次组血小板抗体检测阳性28例(4.15%),1—3次组和>3次组的阳性例数分别为55例(14.32%)和79例(27.15%),血小板抗体阳性率随血小板输注次数增加而升高(z=104.2,P<0.05)。162例阳性患儿疾病分布情况为:血液病142例(18.54%)、实体肿瘤8例(8.99%)、重症感染5例(4.77%)、新生儿血小板减少3例(3.75%)、外科手术患儿3例(1.66%)、其他疾病患儿1例(0.78%),血液病患儿阳性率最高(χ~2=94.321,P<0.05)。结论血小板输注次数与血小板抗体产生密切相关,且疾病本身亦可能导致血小板抗体阳性。Objective To understand the positive rate of platelet antibody in children, and explore the relationship between platelet antibody positivity and the times of platelet transfusion and the diseases. Methods The positive distribution of platelet antibody in 1 350 children recorded from January 2016 to June 2018 in our hospital were statistically described. According to the times of previous platelet transfusion, the cases were divided into three groups: the 0 time group(675 cases), 1-3 times group(384 cases) and > 3 times group(291 cases). The positive rate of platelet antibody and the disease distribution in children with positive platelet antibody in each group were analyzed statistically.Results There were 162 cases with positive platelet antibody among the 1 350 pediatric patients, the positive rate was 12%. Among them, 28 cases were in 0 time group(positive rate 4.15%), 55 in 1-3 times group(positive rate 14.32%) and 79 in > 3 times group(positive rate 27.15%).The positive rate of platelet antibody increased with the times of platelet transfusion(z=104.2, P<0.05). The disease distribution in 162 positive platelet antibody children was as follows: 142 cases with hematological diseases, ranking in the first with a rate of 18.54%(χ^2 = 94.321,P<0.05), followed by 8 cases with solid tumors(8.99%), 5 with severe infection(4.77%), 3 with neonatal thrombocytopenia(3.75%), 3 with surgery(1.66%) and 1 with other diseases(0.78%). Conclusion The production of platelet antibody was positively correlated with the times of transfusion. Meanwhile, the disease itself may contribute to the production of platelet antibodies.

关 键 词：儿童 血小板抗体 血小板输注 血液病 

分 类 号：R457.11[医药卫生—治疗学] R331.143[医药卫生—临床医学]