广西重型β地中海贫血患者贫血和铁超载现状调查  

Investigation on anemia and iron overload in patients with β-thalassemia major in Guangxi

作　　者：李静 周天红 唐卒卒 陈明星 周钧宁 农丕银 卢晓雯 尹晓林 LI Jing;ZHOU Tianhong;TANG Zuzu;CHEN Mingxing;ZHOU Junning;NONG Piyin;LU Xiaowen;YIN Xiaolin(Department of Blood Transfusion, 923rd Hospital of PLA Joint Logistics Support Force,Nanning 530021,China)

机构地区：[1]解放军联勤保障部队第九二三医院输血科,广西南宁530021

出　　处：《中国输血杂志》2019年第2期183-185,共3页Chinese Journal of Blood Transfusion

基　　金：广西自然科学基金(2015GXNSFAA139164)

摘　　要：目的了解广西重型β地中海贫血(TM)患者的贫血及铁超载状况,为其临床治疗提供基础数据和依据,以改善患者生存质量。方法利用地贫管理系统,统计2011—2017年共7年间就诊于本医院的1029名TM患者资料,共测定输血前血红蛋白(Hb)12 119次、血清铁蛋白(SF)4834次,分析Hb、SF的整体情况;每1年的平均Hb、SF情况;不同年龄患者的Hb、SF情况,利用SPSS软件对相关数据进行分析处理。结果患者输血前Hb>90 g/L、(60—90)g/L、(30—60)g/L、<30 g/L分别为28.9%(297/1 029)、49.1%(505/1 029)、19.4%(200/1 029)和2.6%(27/1 029),Hb平均水平与年份及年龄均无明显相关性。87.3%(898/1 029)的TM患者铁超载,46.8%(482/1 029)为重度铁超载(SF>2 500 ng/mL);平均SF水平随着患者年龄的增长呈上升趋势。结论广西的TM患者治疗现状远低于预期,迫切需要加强输血和去铁治疗。Objective To investigate the anemia and iron overload in patients with β-thalassemia major(TM) in Guangxi, and to provide basic data and reference for clinical treatment aiming at improving the quality of life of the patients. Methods From 2011 to 2017, data of 1 029 TM patients in 923rd Hospital of PLA were collected from Management Software of Thalassemia. The levels of hemoglobin(Hb) and serum ferritin(SF) in the patients were measured for 12 119 times and 4 834 times, respectively. The average Hb and SF in each year were calculated. Hb and SF in patients of different ages were analyzed with SPSS software. Results Pretransfuison Hb level of >90 g/L,(60-90)g/L,(30-60)g/L and <30 g/L were 28.9%(297/1 029), 49.1%(505/1 029), 19.4%(200/1 029) and 2.6%(27/1 029), respectively. There was no significant correlation between average Hb level and age or year. Iron overload and severe iron overload(SF>2500 ng/mL) was identified in 87.3%(898/1 029) and 46.8%(482/1 029) of TM patients, respectively;the average SF level increased together with the increase of age. Conclusion The treatment status of TM patients in Guangxi is worse than expected. Regular transfusion and iron chelator therapy are in urgent need to be strengthened.

关 键 词：β地中海贫血重型 贫血 铁超载 

分 类 号：R446.1[医药卫生—诊断学] R331.1[医药卫生—临床医学]