氟砷联合中毒动物模型建立的研究进展  

Progress in the establishment of animal models of combined fluorine and arsenic poisoning

作　　者：张桥清 吴明松 刘建国 Zhang Qiaoqing;Wu Mingsong;Liu Jianguo(The Affiliated Stomatological Hospital of Zunyi Medical University,Zunyi Guizhou 563099,China;The Special Key Laboratory of Oral Diseases Research,Institution of Higher Education in Guizhou Province,theKey Laboratory of Oral Diseases Research of Zunyi City,Zunyi Guizhou 563006,China)

机构地区：[1]遵义医科大学附属口腔医院,贵州遵义563099 [2]贵州省普通高等学校口腔疾病研究特色重点实验室暨遵义市口腔疾病研究重点实验室,贵州遵义563006

出　　处：《遵义医学院学报》2019年第2期232-237,共6页Journal of Zunyi Medical University

基　　金：地方病与少数民族性疾病教育部重点实验室开放基金项目(NO:黔教合KY字【2017】384);贵州省普通高校口腔疾病特色重点实验室开放课题(NO:K005);遵义市汇川区科技计划项目(NO:遵汇科合201632)

摘　　要：氟、砷是存在于自然界中的两种微量化学元素,其适量摄入对人体有益,过量则会引起机体中毒。氟中毒及砷中毒均已构建出较为成熟的动物模型,但氟砷联合中毒动物模型尚不成熟。为建立更好的氟砷联合中毒动物模型,本文对氟砷联合中毒动物模型建立中的吸收与排泄、动物的选择、实验试剂的选择、氟砷中毒途径、时间及剂量、造模设计、造模成功的判断以及氟砷的相互作用关系作一综述。Fluorine and arsenic are two kinds of trace chemical elements that are available in nature.The proper intake is beneficial to the human body.However,excessive intake could cause poisoning.Animal models of fluorosis and arsenic poisoning have been established,but their animal models of combined fluorosis and arsenic poisoning are imperfect.In order to establish a better animal model,this paper reviewed the establishment of animal models of combined fluoride and arsenic poisoning,including the absorption and excretion of fluoride and arsenic,the selection of animals and experimental reagents,the route,time and dose of fluoride and arsenic poisoning,as well as the judgment of successful modeling,the interaction between fluoride and arsenic in the victims.

关 键 词：氟 砷 联合中毒 动物模型 

分 类 号：R599.9[医药卫生—内科学]