地西他滨联合中药治疗不同中医症状与体征评分MDS患者疗效分析  

Therapeutic Effect of Dicitabine Combined with Traditional Chinese Medicine on MDS Patients with Different TCM Symptoms and Signs Score

作　　者：王萍[1] 严峰[1] 王柏山[1] 王思微 彭程 郭立欣 WANG Ping;YAN Feng;WANG Baishan;WANG Siwei;PENG Cheng;GUO Lixin(Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China;Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China)

机构地区：[1]辽宁中医药大学附属医院,辽宁沈阳110032 [2]辽宁中医药大学,辽宁沈阳110847

出　　处：《辽宁中医药大学学报》2019年第5期165-168,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：辽宁省科技厅基金资助项目(20170540595)

摘　　要：目的:探讨地西他滨(DAC)联合中药治疗不同中医症状与体征评分的骨髓增生异常综合征(MDS)患者的疗效分析。方法:诊断MDS患者中筛选30例患者,进行中医症状与体征评分分级,其标准为1级(0～9分)、2级(10～18分)和3级(19～27分),均采用中西医结合治疗。西医方面,患者均采用地西他滨治疗,5 d为1个治疗周期,地西他滨用法为20 mg/(m^2·d),纳入患者均治疗6个周期以上。中医方面,根据评分和辨证分型的不同,采用不同的治疗方法,治疗1个月以上。结果:中西医结合治疗后,1级患者10例,有效例数3例;2级患者10例,有效例数5例;3级患者10例,有效例数6例。结论:通过中医症状与体征评分对MDS患者进行分级后治疗,发现地西他滨(DAC)联合中药治疗对1级患者的疗效较差,2级和3级患者疗效略好,其原因可能与MDS的病理本质和地西他滨的作用靶点直接相关。Objective:To explore the therapeutic effect of dicitabine(DAC)combined with traditional Chinese medicine on patients with myelodysplastic syndrome(MDS)with different scores of symptoms and signs of traditional Chinese medicine(TCM). Methods:30 patients with MDS were selected and graded according to TCM symptoms and signs. The criteria were grade 1(0-9 points),grade 2(10-18 points)and grade 3(19-27 points). All patients were treated with integrated traditional Chinese and Western medicine.For Western medicine,patients were treated with dicitabine for 5 days,and dicitabine for 20 mg/(m^2·d),which included more than 6 cycles of treatment. In the aspect of TCM,different treatment methods are adopted according to different scores and syndrome differentiation types,and the treatment lasts for more than one month. Results:After treatment with integrated traditional Chinese and Western medicine,there were 10 grade 1 patients,3 effective cases;10 grade 2 patients,5 effective cases;10 grade 3 patients,6 effective cases.Conclusion:TCM type classification of MDS patients after the discovery of decitabine(demethylation drugs)combined with Chinese medicine on the curative effect of poor patients with low risk,high risk and high-risk patients,and may be the pathological essence of MDS and decitabine are direct correlation with target.

关 键 词：地西他滨 骨髓增生异常综合征 中医症状与体征评分 辨证分型 去甲基化 

分 类 号：K552[历史地理—历史学]