冠心病气滞血瘀证客观指标的研究进展  

Research Progress of Objective Indicators of Coronary Heart Disease Patients with Qi-Stagnation and Blood-Stasis Syndrome

作　　者：王茹 宋海英[1] 王承龙[1] 王培利[1] WANG Ru;SONG Haiying;WANG Chenglong;WANG Peili(Center for Cardiovascular Diseases, Department of Ctinliology, Xiyuan Hospital, ChinaAcademy of Chinese Medical Sciences,Beijing 100091,China)

机构地区：[1]中国中医科学院西苑医院心血管病中心心血管病研究所,北京100091

出　　处：《辽宁中医杂志》2019年第4期882-884,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81273934);国家重点基础研究计划("973"计划)(2015CB554402)

摘　　要：心血管疾病在全球范围内居各类死亡原因之首,冠心病作为心血管疾病的重要组成部分,其发生与发展与脂质浸润、炎症反应、内皮损伤、血小板聚集、血栓形成等病理过程密切相关。气滞血瘀证是冠心病的一种常见临床证型,该证型的客观化、标准化随着医学的进步取得了长足的发展——在血液流变学、血流动力学、血小板功能、血脂代谢、微循环障碍、代谢组学及蛋白质组学等方面均有体现。但选择出灵敏度强、特异度高且创伤性小的客观指标使气滞血瘀证病因病机与现代医学病理生理融会贯通仍亟待研究解决。本文拟对气滞血瘀型冠心病的客观化指标研究进展做一综述,总结气滞血瘀证冠心病可能的发病机制。Cardiovascular disease has always been a major cause of mortality worldwide. The occurrence and development of coronary heart disease is closely associated with followed physiological processes,including platelet aggregation,dyslipidemia,vascular endothelial injury,inflammatory response,thrombosis and so on. With the improvement upon the medicine,Qi-stagnation and blood-stasis syndrome,as an usual syndrome of coronary heart disease,is gradually objective and standarlized,demonstrating in many aspects as follows: hemorheology,hemodynamics,platelet functions,blood lipid metabolism,microcirculation disturbance,metabonomics,proteomics and so on. What matters us is how to choose sensitive and special objective indicators to combine the etiology and pathogenesis in traditional Chinese medicine theory with pathological physiology in modern medicine. Here we review the research progress of objective indicators and summarize the possible pathogenesis of this syndrome.

关 键 词：冠心病 气滞血瘀证 客观化指标 内皮损伤 综述 

分 类 号：R541.4[医药卫生—心血管疾病]