基质金属蛋白酶-9对川崎病并发冠脉损伤诊断价值的Meta分析  

Meta-analysis of the value of matrix metalloproteinase-9 in the diagnosis of Kawasaki disease complicated with coronary artery injury

作　　者：盈竞男 陈彩霞[1] 高小清 Ying Jingnan;Chen Caixia;Gao Xiaoqing(Department of Pediatrics, Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210000, China)

机构地区：[1]南京医科大学第二附属医院儿内科,江苏南京210000

出　　处：《当代医学》2019年第15期4-7,共4页Contemporary Medicine

摘　　要：目的通过Meta分析探讨基质金属蛋白酶-9(MMP-9)对川崎病并发冠脉损伤的诊断价值。方法计算机检索2006年1月至2018年1月发表的MMP-9诊断川崎病并发冠脉损伤的文献,使用Rev Man 5.3软件进行Meta分析。结果共有19篇文献入选,Meta分析结果显示川崎病并发冠脉损伤患儿血清MMP-9浓度与未合并冠脉损伤组相比差异有统计学意义(P<0.01)。结论血清MMP-9浓度可以作为预测川崎病并发冠脉损伤发生的指标。Objective To investigate the diagnostic value of matrix metalloproteinase-9 (MMP-9) for Kawasaki disease complicated with coronary artery injury by meta-analysis. Methods The literature of MMP-9 for the diagnosis of Kawasaki disease complicated with coronary artery injury published from January 2007 to present was searched and meta-analysis was performed using Rev Man 5.3 software. Results A total of 19 articles were enrolled. The results of meta-analysis showed that the serum MMP-9 concentration in children with Kawasaki disease complicated with coronary artery injury was significantly different from that in patients without coronary artery injury (P<0.01). Conclusion Serum MMP-9 concentration can be used as an indicator to predict the occurrence of Kawasaki disease with coronary artery injury.

关 键 词：川崎病 冠脉损伤 基质金属蛋白酶-9 META分析 

分 类 号：R725.4[医药卫生—儿科]