氯冉酸荷移分光光度法测定注射用头孢唑肟钠  

Spectrophotometry Determination of Ceftizoxime Sodium for Injection Based on Charge Transfer Complex of Ceftizoxime Sodium with Chloranilic Acid

作　　者：张卫[1] 刘昌发[1] 陈萍萍 万晶晶 田圣洁 张雨[1] 李健[1] ZHANG Wei;LIU Chang-fa;CHEN Ping-ping;WAN Jing-jing;TIAN Sheng-jie(Zhengzhou Railway Vocational & Technical College,Zhengzhou 451460,China)

机构地区：[1]河南省郑州铁路职业技术学院药学系,郑州451460

出　　处：《海峡药学》2019年第4期61-63,共3页Strait Pharmaceutical Journal

摘　　要：目的建立测定注射用头孢唑肟钠含量的方法。方法利用氯冉酸与头孢唑肟在乙二醇-乙醇介质中发生荷移反应,形成荷移配合物,采用分光光度法测定。结果荷移配合物在530nm处有最大吸收,表观摩尔吸收系数为1.167×10~3L/(mol·cm),药物浓度在0.005830mg·mL^(-1)～0.1895mg·mL^(-1)内符合朗伯比尔定律。回收率在98.6%～100.8%之间。结论该方法快速、准确,可用于测定药物制剂中头孢唑肟钠的含量。OBJECTIVE To establish a method for rapid determination of Ceftizoxime sodium for injection.METHODS To utilize visible spectrophotometry based on the charge transfer reaction between Ceftizoxime sodium as donor and Chloranilic acid as acceptor in ethylene glycol-alcohol solution.RESULTS The apparent molar absorptivity of complex was 1.167×10^3L/(mol·cm)at 530 nm.Lambert-Beer law was obeyed in the range of 0.005830~0.1895 mg·mL^-1 of Ceftizoxime sodium.The recovery of the samples was within the range of 98.6%~100.8%.CONCLUSION The proposed method is stable,rapid and accurate.It has been applied to the determination of Ceftizoxime sodium in preparation with satisfactory results.

关 键 词：荷移分光光度法 氯冉酸 注射用头孢唑肟钠 

分 类 号：R927[医药卫生—药学]