新型含吡唑基1,2,4-三唑席夫碱的合成  

Synthesis of Novel 1,2,4-Triazole Schiff Bases Containing Pyrazole Moiety

作　　者：王俊岭[1] 冯书晓[1] 谷广娜 马军营[1] Wang Junling;Feng Shuxiao;Gu Guangna;Ma Junying(Chemical Engineering and Pharmaceutics College,Henan University of Science and Technology,Luoyang,Henan 471023,China)

机构地区：[1]河南科技大学化工与制药学院,河南洛阳471023

出　　处：《化学世界》2019年第4期217-220,共4页Chemical World

基　　金：河南省自然科学基金(No.182300410353);河南科技大学博士科研启动基金(No.4008/13480055)资助项目

摘　　要：以5-苯基-3-吡唑甲酰肼(1)为原料,经5-苯基-3-吡唑甲酰肼二硫代甲酸钾(2)与水合肼发生闭环反应制得4-氨基-5-(5-苯基吡唑-3-基)-1,2,4-三唑-3-硫酮(3);化合物3与芳香醛经缩合反应得到6种4-(芳基次甲亚胺基)-5-(5-苯基吡唑-3-基)-1,2,4-三唑-3-硫酮衍生物4a～4f。用IR,~1H NMR,元素分析等对所合成的目标产物结构进行了表征;目标产物存在Z/E异构体,室温下以E式异构体形式为主。5-Phenyl-3-pyrazole-formyl hydrazine (1),six new 4-arylideneamino-5-(5-phenyl-1 H-pyrazol-3- yl)-1,2,4-triazole-3-thiones (3) were prepared via condensation of aromatic aldehydes with 4-amino-5-(5- phenyl-1 H-pyrazole-3-yl)-1,2,4-triazole-3-thione (4a^4f),which was obtained by cyclization of potassium salt of 5-phenyl-1 H-pyrazole-3-carbohydrazinecarbodithioic acid with hydrazine.The structures of target compounds were characterized by IR ,^1 H NMR and elemental analyses.The target compounds have Z/E isomers,while the E isomer is predominating at room temperature.

关 键 词：吡唑 1 2 4-三唑 席夫碱 合成 

分 类 号：O626.2[理学—有机化学]