以L-脯氨酸为手性源的手性离子液体的合成、表征及光学活性  

Synthesis, Characterization and Optical Activity of Chiral Ionic Liquids with L-Proline as Chiral Source

作　　者：刘红霞[1] 王大元[1] 李盼盼[1] Liu Hongxia;Wang Dayuan;Li Panpan(College of Chemistry and Chemical Engineering,Qiqihar University,Qiqihar,Heilongjiang 161006,China)

机构地区：[1]齐齐哈尔大学化学与化学工程学院,黑龙江齐齐哈尔161006

出　　处：《化学世界》2019年第4期243-246,共4页Chemical World

摘　　要：以L-脯氨酸为手性源,通过还原、氨基保护、酯化等反应,合成了L-脯氨酸衍生物3,研究了反应条件对产物收率的影响。将化合物3分别与具有不同取代基的烷基咪唑反应,合成五种氨基酸衍生物为阳离子的手性离子液体4a～4e。对所合成的产物4a～4e进行了结构表征,测定了旋光度,并对其溶解性以及热稳性进行了初步探讨。An L-Proline derivative 3 was prepared via sequential reduction,amino protection and esterification using L-proline as chiral source.The effect of reaction conditions on the yield was investigated.Five chiral ionic liquids with amino acid derivatives as cations were synthesized from the reaction of intermediates 3 with alkyl imidazole with different substituents 4a^4e.The chemical structures of products 4a.4e were characterized,the specific rotations were measured and the solubility and thermal stability were also discussed.

关 键 词：L-脯氨酸 手性离子液体 合成 光学活性 

分 类 号：O629.71[理学—有机化学]