饥饿诱发的大脑自发神经活动改变及其与激素变化的关联  

Effects of hunger on spontaneous brain activity and its relationship with appetite-related hormone levels:A resting-state f MRI study

作　　者：阙建宇 林潇 黄唯真 宫艺邈 师乐[1] 陆林[1,2] QUE Jianyu;LIN Xiao;HUANG Weizhen;GONG Yimiao;SHI Le;LU Lin(Peking University Sixth Hospital,Peking University Institute of Mental Health,NHC Key Laboratory of Mental Health ( Peking University),National Clinical Research Center for Mental Disorders ( Peking University Sixth Hospital),Beijing,100191,China;Peking University,Academy for Advanced Interdisciplinary Studies Peking - Tsinghua Center for Life Science,Beijing,100191,China)

机构地区：[1]北京大学第六医院北京大学精神卫生研究所国家卫生健康委员会精神卫生学重点实验室(北京大学)国家精神心理疾病临床医学研究中心,北京100191 [2]北京大学前沿交叉科学研究院北大-清华生命联合中心,北京100191

出　　处：《中国药物依赖性杂志》2019年第2期106-112,共7页Chinese Journal of Drug Dependence

基　　金：国家重点基础研究发展计划项目(2015CB856400);北京市自然科学基金青年项目(7194336)资助

摘　　要：目的:探索饥饿状态下大脑自发神经活动的变化情况及其与血糖、食欲素和饥饿素水平的相关性。方法:采集22名饥饿状态下(禁食20 h后)及与之匹配的19名非饥饿状态下受试者的静息态f MRI数据,采用双样本t检验比较组间全脑标准化低频振幅值(mean amplitude of low frequency fluctuation,m ALFF)的差异,将差异脑区的m ALFF值提取出来分别与血糖水平、饥饿素和食欲素水平进行Pearson相关分析。结果:与非饥饿组相比,饥饿组受试者左侧脑岛m ALFF值显著增高,右侧前额叶皮层m ALFF值显著降低(单个体素P <0. 001,体素数≥20)。Pearson相关分析显示,饥饿组受试者左侧脑岛m ALFF值与食欲素A水平呈正相关(r=0. 45,P <0. 05)。结论:饥饿状态下脑岛和前额叶皮层的自发神经活动发生改变,且左侧脑岛的自发神经活动与食欲素A水平相关。研究结果提示,脑岛和前额叶皮层脑区的自发神经活动变化与个体饥饿感密切相关。Objective: Investigating the effects of hunger on spontaneous neuronal activity of the brain,and the relationship between spontaneous neuronal activity of the brain and the plasma levels of ghrelin,orexin A and glucose,were also explored.Methods: 22 healthy male Han Chinese were recruited to undergo 20 h of food deprivation,and another 19 matched individuals were on a regular diet. Then all the subjects completed resting-state functional magnetic resonance imaging scan. Two sample t test was applied to explore the difference of mALFF between hunger and non-hunger groups,and then the correlations between mALFF in differentiated brain areas and the levels of ghrelin,orexin A and glucose were also explored.Results: Compared to non-hunger group,hunger group showed increased mALFF in the left insula and decreased mALFF in right prefrontal cortex. Besides,there was a negative correlation between mALFF in the left insula and the plasma orexin A level in hunger group.Conclusion: Changed spontaneous brain activity in the insula and prefrontal cortex were found in hunger state,and there was a positive correlation between spontaneous brain activity in the left insula and the plasma orexin A level in hunger group,which will promote deepen our understanding of the mechanism of hunger feelings.

关 键 词：饥饿 肥胖 自发神经活动 静息态核磁共振 低频振幅 

分 类 号：R445.2[医药卫生—影像医学与核医学] B845[医药卫生—诊断学]