超声辅助2-取代硫醚-5--1,3,4-噁二唑类化合物的合成  

Ultrasound-Assisted Synthesis of 2-Substituted Thioether-5-[5-(4-nitrophenyl)-1 H-pyrazole-3-yl]-1,3,4-oxadiazole Compounds

作　　者：王俊岭[1] 吴峰敏[1] 冯书晓[1] 谷广娜 马军营[1] Wang Junling;Wu Fengmin;Feng Shuxiao;Gu Guangna;Ma Junying(Chemical Engineering and Pharmaceutics College,Henan University of Science and Technology,Luo yang,Henan 471023,China)

机构地区：[1]河南科技大学化工与制药学院,河南洛阳471023

出　　处：《化学世界》2019年第5期282-285,共4页Chemical World

基　　金：河南科技大学博士科研启动(No.13480069)资助项目

摘　　要：以5-(4-硝基苯基)-1 H-吡唑-3-甲酸乙酯(1)为起始原料,经肼解和关环合成了中间体5-[5-(4-硝基苯基)-1 H-吡唑-3-基]-2-巯基-1,3,4-噁二唑(3)。在超声作用下,以乙腈为溶剂,固体K2CO3为缚酸剂,使化合物3与卤代烃反应合成4个含取代吡唑基的1,3,4-噁二唑硫醚类化合物4a～4d,该法具有反应时间短、产率较高和操作简便等特点。产物结构经元素分析、IR、1 H NMR表征。5-[5-(4-nitrophenyl)-1 H-pyrazole-3-yl]-2-mercapto-1,3,4-oxadiazole (3) was obtained from ethyl 5-(4-nitrophenyl)-1 H-pyrazole-3-carboxylate (1) through the hydrazinolysis and cyclization.Four 2- substituted thioether-5-[ 5-(4-nitrophenyl)-1 H-pyrazole-3-yl]-1,3,4-oxadiazole compounds 4a^4d were then synthesized by the reaction of 3 and alkyl halides using potassium carbonate as acid-accepter in acetonitrile uunder ultrasound irradiation.This method is of the advantages of good yields,short reaction time and easy operation.The structures of products were characterized by IR,^1 H NMR and elemental analyses.

关 键 词：吡唑 1 3 4-噁二唑硫醚 超声波辐射 合成 

分 类 号：O626.2[理学—有机化学]