N-烷基-1,2-苯并异噻唑啉-3-酮化合物的合成  

Synthesis of N-Alkyl-1,2-benzisothiazdin-3-one

作　　者：张可青 王建华 王敏 布仁 Zhang Keqing;Wang Jianhua;Wang Min;Bu Ren(School of Pharmaceutical Science,Inner Mongolia Medical University,Hohhot,Inner Mongolia 010110,China)

机构地区：[1]内蒙古医科大学药学院,内蒙古呼和浩特010110

出　　处：《化学世界》2019年第5期291-294,共4页Chemical World

基　　金：内蒙古医科大学实验室开放基金(No.2017ZN29)资助项目

摘　　要：N-烷基-1,2-苯并异噻唑啉-3-酮类化合物具有优异的杀菌防腐性能,其不使用卤素的清洁合成方法尚未见文献报道。以二硫化二苯甲酸为起始原料,通过酰氯化、酰胺化制得两个N-烷基二硫化二苯酰胺,然后在强碱性溶液中将上述酰胺与双氧水进行氧化合环反应,得到两个N-烷基苯并异噻唑啉酮化合物。产物结构经红外和核磁表征。N-Alkyl-1,2-benzisothiazdin-3-one is a kind of fungicides with efficient performance,but the green synthetic method of N-alkyl-1,2-benzisothiazdin-3-one without halogen has not been reported until now.Two N-alkyl-benzisothiazdin-3-ones were prepared from 2,2-dithiobis-benzoic acid by chloridization,acylation and oxidation with hydrogen peroxide in alkaline solution.The structure of products was identified by IR and ^1 H NMR spectroscopy.

关 键 词：N-烷基-1 2-苯并异噻唑啉-3-酮 杀菌剂 二硫化二苯甲酸 氧化反应 

分 类 号：TQ455.4[化学工程—农药化工]