SPDEF在气道上皮杯状细胞化生中的作用  

Role of SPDEF in the regulation of goblet cell metaplasia of airway epithelium

作　　者：仲秀华 曾晓宁 Zhong Xiuhua;Zeng Xiaoning(Department of Pulmonary & Critical Care Medicine the First Affiliated Hospital of NMU, Nanjing 210029 , China)

机构地区：[1]南京医科大学第一附属医院呼吸与危重症医学科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2019年第4期614-618,共5页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省青年医学人才项目(QNRC2016599)

摘　　要：含SAM尖端结构域的E26转化特异性因子(SAM pointed domain containing E26 transformation-specific transcription factor,SPDEF)是ETS转录因子家族的重要成员。最初认为,作为前列腺上皮特异性转录因子,SPDEF调控了前列腺的发育与前列腺癌的发生发展。然而,新近研究发现呼吸系统也存在SPDEF表达,对气道上皮的分化起核心作用,尤其是杯状细胞的增生与化生。鉴于杯状细胞对于气道内环境的稳定至关重要,深入理解SPDEF如何参与调控杯状细胞化生,不仅有助于深化对气道异常分泌不同机制的认识,还可为相关呼吸系统疾病的诊治提供新思路。本文通过对近年来SPDEF调控杯状细胞功能的系列研究进行综述,为调控气道分泌新药的研发提供新思路。The SAM pointed domain containing ETS transcription factor(SPDEF)is an important member of the E26 transformation-specific transcription factor family. SPDEF is initially identified in prostatic epithelium and considered to be involved in prostate development and prostate cancer progression. However,recent studies revealed that SPDEF is also expressed in the respiratory system.It is pretty crucial for the differentiation of airway epithelium,especially for the proliferation and metaplasia of goblet cells. Due to the importance of goblet cells in respiratory health,extended understanding of SPDEF function not only helps us to illuminate the mechanism of abnormal mucus secretion but also open new perspectives for the management of these related diseases. This review mainly focuses on the recent data which studied the role of SPDEF in goblet cell control,highlighting a novel profile of SPDEF as a new target in mucus secretion moderation.

关 键 词：杯状细胞 SPDEF 化生 黏蛋白 异常分泌 

分 类 号：R562[医药卫生—呼吸系统] R563[医药卫生—内科学]