73例支气管肺炎患儿热毒宁注射液致不良反应报告的相关因素分析  

Analysis on Related Factors of Reports of Adverse Drug Reaction Induced by Reduning Injection in 73 Children's with Bronchopneumonia

作　　者：曹政[1] 石祥奎 张静[1] 黄亭 刘源[1] CAO Zheng;SHI Xiang-kui;ZHANG Jing;HUANG Ting;LIU Yuan(Xuzhou Maternity and Child Health Care Hospital,Xuzhou Jiangsu 221009,China)

机构地区：[1]徐州市妇幼保健院,江苏徐州221009

出　　处：《抗感染药学》2019年第3期476-479,共4页Anti-infection Pharmacy

摘　　要：目的:分析热毒宁注射液用于治疗儿童支气管肺炎致不良反应(ADR)发生的原因与特点,为临床安全合理用药提供参考。方法:抽取2014年1月—2018年12月间收集上报的儿童支气管肺炎使用热毒宁注射液致ADRs患者73例资料,统计其患者性别、年龄和给药剂量、ADRs发生时间、联合用药情况、ADRs累及器官/系统及临床表现以及转归情况,分析其热毒宁注射液致ADRs的发生原因与特点。结果:73例ADRs资料中,男性患儿46例占63.01%;发生ADRs患儿均<4岁,且随着给药剂量的增加,其发生率呈现上升趋势;ADRs发生在给药后30 min内占82.19%,主要与药物联用有关;临床表现以皮肤及其附件、全身性损害为主,分别占74.41%和16.28%;ADRs症状大多数在停用热毒宁注射液后或及时对症处理后的1 h内好转或消失。结论:热毒宁注射液致儿童ADRs大多发生在用药后30 min内,临床应加强监护,药物随用随配;联用药物应及时冲管,以减少或避免ADRs的发生。Objective: To analyze the causes and characteristics of the adverse drug reactions(ADRs) caused by Reduning injection in children’s bronchopneumonitis, and to provide a reference for clinical safety and rational drug use.Methods: Data of 73 patients of ADRs caused by Reduning injection in children with bronchopneumonia were collected from January 2014 to December 2018. The sex, age, dose, time of occurrence of ADRs, combination of drugs, involvement of organs/systems and clinical manifestations of ADRs, and outcome were computed. The causes and characteristics of ADRs induced by Reduning injection were analyzed. Results: Among the 73 cases of ADRs, 46 cases were male, accounting for 63.01%. All children with ADRs were Less than 4 years old, and the incidence increased with the increase of dosage. ADRs occurred within 30 minutes after administration, accounting for 82.19% which was mainly related to drug combination. The main clinical manifestations were in skin and its appendages and systemic lesions, accounting for 74.41% and 16.28%, respectively. Most of the symptoms of ADRs improved or disappeared within 1 hour after withdrawal of Reduning injection or after prompt symptomatic treatment. Conclusion: ADR in children induced by Reduning injection commonly occurred within 30 minutes after administration. To reduce the incidence of ADR,we should conduct the injection immediately after the intravenous drug configuration,and we should do flushing the infusion tube if there are drug combinations.

关 键 词：热毒宁 不良反应 支气管肺炎 发生原因与特点 

分 类 号：R969.3[医药卫生—药理学]