比索洛尔治疗不稳定型心绞痛患者的疗效及对ESM-1、Myo的影响  

Therapeutic effect of bisoprolol on patients with unstable angina pectoris and its effects on ESM-1 and Myo

作　　者：高海英 赵惠强 李俊超 黄红丽 李飞 GAO Hai-ying;ZHAO Hui-qiang;LI Jun-chao;HUANG Hong-li;LI Fei(Department of Emergency,,Beijing Prison Administration Central Hospital,Beijing 100054,China;Department of Medicine,Beijing Prison Administration Central Hospital,Beijing 100054,China;Department of Medicine for Prisoners,Beijing Prison Administration Central Hospital,Beijing 100054,China;Department of Cardiology,Center of Cardiovascular Disease,Beijing Friendship Hospital Affiliated to Capital Medical University,Beijing 100050,China;Department of Internal Medicine,Qinghe Branch Hospital,Beijing Prison Administration,Tianjin 300481,China)

机构地区：[1]北京监狱管理局中心医院急诊科,北京100054 [2]首都医科大学附属北京友谊医院心血管病中心心内科,北京100050 [3]北京监狱管理局清河分局医院内科,天津300481 [4]北京监狱管理局中心医院内科,北京100054 [5]北京监狱管理局中心医院罪犯内科,北京100054

出　　处：《实用药物与临床》2019年第5期518-521,共4页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨比索洛尔治疗不稳定型心绞痛患者的疗效及对内皮细胞特异分子-1(ESM-1)、肌红蛋白(Myo)的影响。方法选择2014年3月至2016年3月我院和友谊医院心内科接诊的80例不稳定型心绞痛患者进行研究,通过随机数表法分为观察组和对照组,各40例。对照组给予辛伐他汀治疗,观察组给予比索洛尔联合辛伐他汀进行治疗,两组均以4周为1个疗程,连续治疗2个疗程。比较两组临床疗效、治疗前后血清ESM-1和MYO水平、每周心绞痛发作次数和持续时间,并比较治疗期间不良反应发生情况。结果治疗后,观察组临床疗效总有效率为95.00%(38/40),明显高于对照组的72.50%(29/40)(P<0.05);治疗后,两组各血清ESM-1和MYO水平较治疗前均显著降低(P<0.05),观察组血清ESM-1和MYO水平均明显低于对照组(P<0.05);治疗前,两组每周心绞痛发作次数和持续时间比较差异无统计学意义(P>0.05);治疗后,两组每周心绞痛发作次数和持续时间较治疗前均显著降低(P<0.05),观察组每周心绞痛发作次数少于对照组(P<0.05),且持续时间较对照组缩短(P<0.05);观察组患者不良反应总发生率为5.00%,明显低于对照组的22.50%,两组比较差异有统计学意义(P<0.05)。结论不稳定型心绞痛患者应用比索洛尔的疗效显著,可明显改善患者的临床症状,减少心绞痛发作次数和持续时间,其内在机制可能与降低血清ESM-1、Myo的表达相关。Objective To investigate the efficacy of bisoprolol in the treatment of unstable angina pectoris and its effects on endothelial cell specific molecule-1(ESM-1)and myoglobin(Myo).Methods Totally 80 patients with unstable angina pectoris admitted to our hospital and Department of Cardiology in the Friendship Hospital from March 2014 to March 2016 were selected for the study;the patients were divided into observation group and control group by random number table method,40 cases in each group.Control group was treated with simvastatin,and observation group was treated with bisoprolol combined with simvastatin.Both groups were treated for 2 consecutive courses of treatment with 4 weeks as one course of treatment.The clinical efficacy,serum ESM-1 and MYO levels before and after treatment,the number and duration of angina attacks per week were compared between the two groups,and adverse reactions during treatment were compared.Results After treatment,the total effective rate of clinical efficacy in observation group was 95.00% (38/40),which was significantly higher than 72.50% (29/40)in control group(P<0.05).After treatment,the serum ESM-1 and MYO levels of both groups were significantly decreased(P<0.05),and the serum levels of ESM-1 and MYO in observation group were significantly lower than those in control group(P<0.05).Before treatment,there was no significant difference in the frequency or duration of angina pectoris per week between the two groups(P>0.05).After treatment,the weekly angina attack frequency and duration in both groups were significantly decreased(P<0.05),and the weekly angina attack frequency and duration in observation group were significantly lower than those in control group(P<0.05).The total incidence of adverse reactions in observation group was 5.00% ,which was significantly lower than 22.50% in control group(P<0.05).Conclusion The effect of bisoprolol in patients with unstable angina pectoris is remarkable.It can significantly improve the clinical symptoms and reduce the number and duration

关 键 词：比索洛尔 不稳定型心绞痛 内皮细胞特异分子-1 肌红蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]