沙美特罗替卡松联合孟鲁司特钠治疗小儿支气管哮喘急性发作的疗效  

Curative Effect of Salmeterol-Fluticasone Combined with Montelukast on Acute Attack of Bronchial Asthma in Children

作　　者：陈智锋[1] 吕波[1] 马爱芬[1] 谭静 CHEN Zhi-feng;LV Bo;MA Ai-fen;TAN Jing(Department of Pediatrics,Zhaoqing First People’s Hospital,Zhaoqing 526020,China)

机构地区：[1]肇庆市第一人民医院儿科,广东肇庆526020

出　　处：《实用临床医学（江西）》2019年第2期49-51,共3页Practical Clinical Medicine

摘　　要：目的探讨沙美特罗替卡松联合孟鲁司特钠治疗小儿支气管哮喘急性发作的临床疗效。方法将120例支气管哮喘急性发作患儿按随机数字表法分为对照组和观察组,每组60例。2组均采用常规治疗,同时采用地塞米松注射液、氨茶碱注射液和沙美特罗替卡松吸入剂治疗。在此基础上,观察组采用孟鲁司特钠片治疗。观察2组治疗12周后日间、夜间的支气管哮喘症状评分,最大呼气流量(PEF)、第1秒用力呼气容积(FEV1)值,FEV1/用力肺活量(FVC)比值,血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、嗜酸性粒细胞阳离子蛋白(ECP)和尿白三烯E4(LTE4)水平的变化,临床症状、体征(咳嗽、喘憋或气促,湿性啰音、哮鸣音)消失时间及临床疗效。结果观察组总有效率明显高于对照组(96.67%比81.67%,P<0.05)。观察组治疗12周后日间、夜间的支气管哮喘症状评分及血清IL-6、TNF-α、ECP水平和尿LTE4水平均明显低于对照组,咳嗽、喘憋或气促和湿性啰音、哮鸣音的消失时间均明显短于对照组,PEF、FEV1值和FEV1/FVC比值均明显高于对照组(均P<0.05)。结论沙美特罗替卡松联合孟鲁司特钠治疗小儿支气管哮喘急性发作疗效显著。Objective To explore the clinical effect of salmeterol-fluticasone combined with montelukast sodium on acute attack of bronchial asthma in children. Methods A total of 120 children with acute attack of trachea asthma were randomly divided into control group and observation group,with 60 children in each group.Both groups were given routine therapy supplemented with dexamethasone injection,aminophylline injection and salmeterol-fluticasone inhalation.On this basis,the observation group was treated with montelukast sodium tablets.The daytime/nighttime asthma symptom scores,peak expiratory flow(PEF),forced expiratory volume in 1 second(FEV1),FEV1/forced vital capacity(FVC) ratio,serum levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α) and eosinophil cationic protein(ECP) and urinary levels of leukotriene E4(LTE4) were measured after treatment for 12 weeks.Furthermore,the time to disappearance of clinical symptoms and signs(cough,wheeze or shortness of breath,wet rale,wheezing rale) and curative effect were observed in both groups. Results The total effective rate in observation group was higher than that in control group(96.67% vs 81.67%, P <0.05).In addition,compared with control group,montelukast sodium reduced the scores of asthma symptoms,serum levels of IL-6,TNF-α and ECP and urine levels of LTE4,shortened the time to disappearance of cough,wheeze or shortness of breath,wet rale and wheezing rale,and increased the PEF,FEV 1 and FEV1/FVC ratio( P <0.05). Conclusion The combined treatment with salmeterol-fluticasone and montelukast sodium is effective for acute attack of bronchial asthma in children.

关 键 词：支气管哮喘 急性发作 沙美特罗替卡松 孟鲁司特钠 疗效 小儿 

分 类 号：R725.6[医药卫生—儿科]