卵巢多囊样改变不孕患者的临床特征分析  

Analysis of clinical features in patients with ovarian polycystic change infertility

作　　者：胡仲梅 王露娟 何雪瑞 廖娟 HU Zhongmei;WANG Lujuan;HE Xuerui;LIAO Juan(Department of Gynecology and Obstetrics,Affiliated Hospital of Zunyi Medical University,Zunyi,Guizhou 563003,China)

机构地区：[1]遵义医科大学附属医院妇产科,贵州遵义563003

出　　处：《现代医药卫生》2019年第10期1493-1496,1499,共5页Journal of Modern Medicine & Health

摘　　要：目的了解卵巢多囊样改变(PCO)不孕患者的临床特征,探讨PCO与多囊卵巢综合征(PCOS)是否存在相关性。方法选取2017年6月至2018年6月因不孕症就诊于该院生殖中心年龄小于或等于35岁的女性患者180例,其中经阴道超声检查诊断为PCO患者130例,根据PCOS诊断中华人民共和国卫生行业标准分为PCOS组(70例)和PCO组(60例),其余50例作为非PCO组;完善各组患者性激素、排卵情况及黄体功能检测,比较各组间均值及率的差异。结果 (1)血清基础性激素:3组患者雌二醇、孕激素、泌乳素比较,差异均无统计学意义(P>0.05);PCOS组患者硫酸脱氢表雄酮、黄体生成素/卵泡刺激素均明显高于PCO组,PCO组患者明显高于非PCO组,PCO组、非PCO组患者黄体生成素、总睾酮水平均明显低于PCOS组,差异均有统计学意义(P<0.05);(2)排卵情况:3组患者排卵情况比较,差异均有统计学意义(P<0.05);(3)黄体功能:3组患者黄体中期性激素水平比较,差异无统计学意义(P>0.05);PCO组、非PCO组患者中正常排卵患者黄体功能不足发生率比较,差异有统计学意义(P<0.05);而3组患者中异常排卵患者黄体功能不足发生率比较,差异无统计学意义(P>0.05)。结论 PCO患者大多数已具有不同程度的生殖内分泌异常,故不能视为健康人群,对有生育要求的患者应早期给予临床关注,必要时给予临床干预,以降低不孕症发生率;PCO患者发生的生殖内分泌改变与PCOS具有相似性,提示PCO与PCOS可能存在相关性,但需进一步研究证实。Objective To understand the clinical features of infertility patients with polycystic ovary(PCO),and to investigate whether the correlation existing between PCO and polycystic ovary syndrome(PCOS). Methods One hundred and eighty infertile female patients aged ≤35 years old in the reproductive center of this hospital from June 2017 to June 2018 were selected,including 130 cases of PCO diagnosed by transvaginal ultrasonograph,and divided into the PCOS group ( n =70) and PCO group( n =60) according to the PCOS diagnostic standard of Health Industry Standard of the People′s Republic of China,the other 50 cases were the non-PCO group.The detections of sex hormones,ovulation situation and corpus luteum function were perfected in each group.The differences of mean values and rates were compared among various groups. Results (1) Serum basal hormones:the levels of E2,P and PRL had no statistical difference among the three groups ( P >0.05);DHEAS and LH/FSH in the PCOS group were significantly higher than those in the PCO group,while the PCO group was significantly higher than the non-PCO group,the LH and testosterone (T) in the PCO group and non-PCO group were significantly lower than those in the PCOS group,and the differences were statistically significant ( P <0.05).(2) In the ovulation situation:the ovulation situation had statistical difference among the three groups ( P <0.05).(3) In the corpus luteum function:the metaphase corpus luteum hormone had no statistical difference among the three groups( P >0.05);the occurrence rate of corpus luteum functional impairment had statistical difference among the patients with normal ovulation in the PCO group and non-PCO group( P <0.05),but the occurrence rate of corpus luteum functional impairment had no statistical difference among the patients with abnormal ovulation in the three groups ( P >0.05). Conclusion The most of the patients with PCO have different degrees of reproductive endocrine abnormalities,therefore,they can not be regarded as normal population,the patien

关 键 词：多囊卵巢综合征 性腺甾类激素 排卵监测 黄体溶解 卵巢多囊样改变 

分 类 号：R711.75[医药卫生—妇产科学]