正品、伪品治糜康栓的差异特征元素分析及无机元素特征谱  

Research on differential feature elements and inorganic elements characteristic spectrum of authentic and fake Zhimikang Shuan

作　　者：刘圣金[1] 乔婷婷[1] 马瑜璐[1] 房方[1] 林瑞超[2] 孙云飞[3] 吴德康[1] LIU Sheng-jin;QIAO Ting-ting;MA Yu-lu;FANG Fang;LIN Rui-chao;Sun Yun-fei;WU De-kang(Jiangsu Provincial Key Laboratory for Functional Substance of Chinese Medicine,Jiangsu Provincial Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,Nanjing University of Chinese Medicine,Nanjing 210023,China;Beijing University of Chinese Medicine,Beijing 100029,China;Jiangsu Province Hospital of Traditional Chinese Medicine,Nanjing 210029,China)

机构地区：[1]南京中医药大学江苏省中药资源产业化过程协同创新中心江苏省中药功效物质重点实验室,江苏南京210023 [2]北京中医药大学,北京100029 [3]江苏省中医院,江苏南京210029

出　　处：《中成药》2019年第5期1096-1101,共6页Chinese Traditional Patent Medicine

基　　金：国家自然科学基金项目(81673566;81573556);2015年度中医药行业专项(2015468004-2-1);江苏高校"青蓝工程"项目(2017);江苏高校品牌专业建设工程资助项(PPZY2015A070);江苏高校优势学科建设工程资助项目(ysxk-2010)

摘　　要：目的研究正品治糜康栓(方中枯矾由钾明矾制备)和伪品治糜康栓(方中枯矾由铵明矾制备)的差异特征元素,并建立无机元素特征图谱。方法采用微波消解-电感耦合等离子体原子发射光谱/质谱(ICP-OES/MS)技术测定正品、伪品治糜康栓中18种无机元素的含有量,通过SPSS 16.0、SIMCA-P 13.0、t检验及秩和检验对样品进行聚类分析及差异特征元素分析,建立正品、伪品治糜康栓的无机元素特征谱。结果伪品治糜康栓中Al含有量最高,K、Fe、Mn、Zn、Ga、Cr次之;正品治糜康栓中K含有量最高,Al、Fe、Mn、Zn、Cr次之;其他微量元素含有量均较低。16批样品聚类为2类。结论共筛选出12种差异特征无机元素(P<0.05)。建立了正品、伪品治糜康栓中16种无机元素特征谱,可作为治糜康栓质量控制手段之一。AIM To research the differential feature elements of authentic Zhimikang Shuan which calcined alumen in formulation processed by alumen and the fake one which by ammonium alumen,and to establish the spectrums of inorganic elements characteristic.METHODS The contents of eighteen inorganic elements both in authentic Zhimikang Shuan and the fake one were determined by means of microwave digestion-ICP-OES/MS.SPSS 16.0 was used for cluster analysis while SIMCA-P 13.0,t-test and Rank-Sum test were used to analyze the differences of the inorganic elements.The characteristic spectrum of the inorganic elements of authentic Zhimikang Shuan and the fake one were established.RESULTS The content of Al was the highest in fake Zhimikang Shuan with K,Fe,Mn,Zn,Ga and Cr decreasing,while K was the highest in authentic Zhimikang Shuan with Al、Fe、Mn、Zn and Cr decreasing.The contents of other trace elements were low.Sixteen batches of samples were divided into two types.CONCLUSION Twelve inorganic differential feature elements(P<0.05)are screened out.Characteristic spectrums of sixteen inorganic elements in authentic Zhimikang Shuan and the fake one are established.This method can be used as one of the quality control means of Zhimikang Shuan.

关 键 词：治糜康栓 无机元素 电感耦合等离子体原子发射光谱/质谱 特征图谱 

分 类 号：R284.1[医药卫生—中药学]