慢性阻塞性肺疾病稳定期患者肺功能、营养状况及氧化应激能力分析  

Analysis of pulmonary function,nutritional status and oxidative stress ability in patients with chronic obstructive pulmonary disease in stable stage

作　　者：薛华 魏胜全[2] 王智杰 翟梅 王小卫 丁俊冰 梁杰 亢锴 XUE Hua;WEI Shengquan;WANG Zhijie;ZHAI Mei;WANG Xiaowei;DING Junbing;LIANG Jie;KANG Kai(Department of Respiration,Xianyang First People′s Hospital,Xianyang,Shanxi,712000;Department of Respiration,Baoji People′s Hospital,Baoji,Shaanxi,721000)

机构地区：[1]陕西省咸阳市第一人民医院呼吸科,陕西咸阳712000 [2]陕西省宝鸡市人民医院呼吸科,陕西宝鸡721000

出　　处：《实用临床医药杂志》2019年第9期65-68,共4页Journal of Clinical Medicine in Practice

摘　　要：目的 探讨慢性阻塞性肺疾病(COPD)稳定期患者肺功能、营养状况及氧化应激能力。方法 选择65例COPD患者设为观察组,另选择35名健康体检者设为对照组。比较2组脂联素和肺功能水平,采用微型营养评定(MNA)进行营养评估,并检测血清还原型谷胱甘肽(GSH)、丙二醛(MDA)、超氧化物歧化酶(SOD)和总抗氧化能力(TAC)水平。结果 观察组脂联素水平显著低于对照组,肺功能指标第1秒用力呼气容积占预计值百分比(FEV1%)、肺活量(FVC)和FEV1/FVC也显著低于对照组(P<0.05);对照组入选者营养状况良好,观察组65例患者中,营养良好者35例(53.85%)、营养不良者30例(46.15%),观察组中营养良好者MNA总分显著高于营养不良者(P<0.05);观察组患者GSH、SOD、TAC显著低于对照组,MDA显著高于对照组(P<0.05)。结论 COPD稳定期患者肺功能、营养状况及氧化应激能力三者关系密切,营养不良可能会导致氧化应激增强,进而造成肺功能水平下降,因此对患者采取干预营养状况的措施可取得良好的效果。Objective To analyze the pulmonary function, nutritional status and oxidative stress ability of patients with chronic obstructive pulmonary disease (COPD) in stable stage. Methods A total of 65 COPD patients in our hospital were selected as experimental group, and another 35 healthy people as control group. The levels of adiponectin and pulmonary function were compared between the two groups. The nutritional assessment was performed by micronutrient assessment (MNA), and the levels of serum reduced glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD) and total antioxidant capacity (TAC) were measured. Results The level of adiponectin in the experimental group was significantly lower than that in the control group. The pulmonary function index such as ratio of forced expiratory volume in one second to predicted value(FEV 1%), forced vital capacity(FVC) and ratio of forced expiratory volume in one second to forced vital capacity(FEV 1/FVC) in the experimental group were also significantly lower than those in the control group ( P <0.05). The nutritional status of all the participants in the control group was good. Among the 65 cases in the experimental group, 35 cases (53.85%) were well-nourished and 30 cases (46.15%) were malnourished. The total MNA score of the well-nourished participants in the experimental group was significantly higher than that of those with malnutrition ( P <0.05). The GSH,SOD and TAC of the experimental group were significantly lower, and MDA was higher than thoseof the control group( P <0.05). Conclusion The pulmonary function, nutritional status and oxidative stress ability of COPD patients in stable stage are closely related. Malnutrition may lead to increased oxidative stress, which may lead to a decline in pulmonary function. Therefore, interventions should be taken to improve the nutritional status of COPD patients.

关 键 词：慢性阻塞性肺疾病 肺功能 营养状况 氧化应激 

分 类 号：R563[医药卫生—呼吸系统]