清热利湿解毒法治疗带状疱疹湿热内蕴证疗效及对神经肽影响观察  

Clinical Observation of Clearing Heat and Eliminating Dampness and Detoxification Method in Treating Herpes Zoster with Interior Dampness-Heat Syndrome and Its Impacts on Neuropeptide

作　　者：刘云[1] 李伟泽[1] 刘厚颖[1] 李蓉[1] 刘裕萍[1] LIU Yun;LI Weize;LIU Houying;LI Rong;LIU Yuping(The Second Affiliated Hospital of Guiyang TCM College, Guiyang 550001 , Guiyang, China)

机构地区：[1]贵阳中医学院第二附属医院,贵州贵阳550001

出　　处：《中华中医药学刊》2019年第5期1190-1192,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：贵州省科学技术基金项目(黔科合J字[2014]2038号)

摘　　要：目的:观察由清热利湿解毒法组成之痛痒灵汤治疗带状疱疹湿热内蕴证的临床疗效及对神经肽的影响。方法:150例带状疱疹湿热内蕴证患者随机分为中药组、西药组和综合组各50例,中药组以痛痒灵汤外涂,西药组以利巴韦林静滴,综合组以痛痒灵汤外涂联合利巴韦林静滴。14 d为1个疗程。比较临床疗效、临床症状改善时间、视觉模拟(VAS)评分,放免法检测血浆神经肽,记录不良反应。结果:综合组总有效率94.0%,明显高于西药组的66.0%和中药组的70.0%(P<0.05)。综合组止疱、结痂、治愈时间、VAS评分及血浆SP含量均明显低于其它两组,血浆β-EP含量明显高于其它两组(P<0.05)。3组均无明显不良反应出现。结论:清热利湿解毒法之痛痒灵汤治疗带状疱疹湿热内蕴证有较好的临床效果。Objective: To observe the clinical effect of clearing heat and eliminating dampness and detoxification method in treating herpes zoster with interior dampness-heat syndrome and its impacts on neuropeptide. Methods:A total of 150 patients were randomly divided into traditional Chinese medicine(TCM) group(50 cases), western medicine group(50 cases) and comprehensive group(50 cases). The Chinese medicine group was treated with Tongyangling Decoction. The western medicine group was injected with ribavirin intravenously. The comprehensive group was treated with Tongyangling Decoction and injected ribavirin intravenously. All treated for 14 days,the clinical efficacy, the time of clinical symptoms improvement and VAS score were compared. The plasma level of neuropeptide was determined by radioimmunoassay and the adverse reactions were recorded. Results: For the comprehensive group, the clinical efficiency was 94.0%, which was higher than that in western medicine group(66.0%) and TCM group(70.0%)(P<0.05). Compared with the other two groups, the comprehensive group’s stopping herpes time, lesion scabby time and healing time were shorter. The VAS score and the plasma level of SP were lower and the plasma level of β-EP was higher(P<0.05). No obvious adverse reactions were observed in the three groups. Conclusion: The clearing heat and eliminating dampness and detoxification method is effective for herpes zoster with interior dampness-heat syndrome.

关 键 词：清热利湿解毒法 带状疱疹 湿热内蕴证 临床疗效 神经肽 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]