比较丹参川芎嗪与丹参注射液治疗急性脑梗死的有效性及安全性的系统评价  

A Meta Analysis of Danshen Chuanxiongqi Injection Compared with Danshen Injection on Acute Cerebral Infarction

作　　者：李晓岩[1] 徐卉[2] 徐国良[1] Li Xiaoyan;Xu hui;Xu Guoliang(The First Hospital of Jilin University-the Eastern Division,Jilin,Changchun 130031,China)

机构地区：[1]吉林大学第一医院二部,吉林长春130031 [2]吉林大学第一医院,吉林长春130021

出　　处：《中国中医急症》2019年第5期786-788,813,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：吉林省科委资助项目(2015Y034-4)

摘　　要：目的应用Meta分析对丹参川芎嗪与丹参这两种注射液对于治疗急性脑梗死的有效性及安全性进行分析。方法通过计算机检索Cochrane试验资料库(2018年第1期)、Embase (1966年至2018年3月)、Pubmed(1966年至2018年3月)、中国学术文献总库(CNKI)(1979年至2018年3月)、中文科技期刊数据库(1989年至2018年3月)、万方数字期刊库(1981年至2018年3月),按照Meta分析的纳入排除标准筛选文献、评估文献质量,提取所需数据,应用RevMan5.3软件对提取的数据进行Meta分析。结果初步检索出112篇文献,根据纳入排除标准有13篇文献入选。依据症状疗效来分析:χ2=8.84,df=12,P=0.72,合并OR=4.01,95%CI[2.89,5.58],Z=8.26(P <0.00001),并且无明显不良反应。结论丹参川芎嗪注射液比丹参注射液治疗急性脑梗死疗效更好且较安全。Objective: To analyze the efficacy and safety of Danshen Chuanxiongqi Injection and Danshen Injection on acute cerebral infarction. Methods: Computers was used to search Cochrane trial database(issue 01 of 2018),Embase(1966-2018.03),Pubmed(1966-2018.03),CNKI(1979-2018.03),Chinese Science and Technology Journal Database(1989-2018. 03),Wanfang Digital Periodicals Library(1981-2018.03). According to the inclusion and exclusion criteria of meta-analysis,the literature was screened;the quality of literature was evaluated,and the required data was extracted. RevMan 5.3 software was used for meta-analysis of the extracted data. Results: An initial search of 112 documents was conducted,and 13 articles were selected according to the inclusion criteria. Analysis based on the effect of symptoms:χ^2=8.84,df=12,P= 0.72,combined OR=4.01,95%CI[2.89,5.58],Z = 8.26(P < 0.00001) with no significant adverse reactions. Conclusion: Danshen Chuanxiongqi Injection is more effective and safer on acute cerebral infarction compared with Danshen Injection.

关 键 词：急性脑梗死 丹参川芎嗪注射液 丹参注射液 META分析 

分 类 号：R541.4[医药卫生—心血管疾病]