菜头肾化学成分研究  

Studies on Chemical Constituents of Championella sarcorrhiza

作　　者：屈玲霞 王扬 刘永巧[1,2,3] 李龙宇[1,2,3] 邹小华 胡晓焱 陆成豪 褚夏燕 徐暾海 朱寅荻 QU Ling-xia;WANG Yang;LIU Yong-qiao;LI Long-yu;ZOU Xiao-hua;HU Xiao-yan;LU Cheng-hao;CHU Xia-yan;XU Tun-hai;ZHU Yin-di(School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing 100029,China;Health Cultivation Key Laboratory of Beijing,Beijing 100029,China;Health Cultivation Key Laboratory of the Ministry of Education,Beijing 100029,China;School of Pharmacy,Wenzhou Medical University,Wenzhou 325035,China)

机构地区：[1]北京中医药大学中药学院,北京100029 [2]中医养生学北京市重点实验室,北京100029 [3]中医养生学教育部重点实验室,北京100029 [4]温州医科大学药学院,浙江温州325035

出　　处：《中国现代中药》2019年第4期438-440,共3页Modern Chinese Medicine

基　　金：国家科技部国际科技合作项目(2010DFB33260)

摘　　要：目的:研究菜头肾的化学成分。方法:综合运用硅胶、ODS、Sephadex LH-20柱色谱及制备高效液相色谱等方法,对菜头肾提取物进行化学成分分离纯化,利用理化性质和NMR波谱特征进行结构鉴定。结果:从中分离鉴定了7种成分,分别为cornoside(1)、(-)-(2R)-1-O-β-D-glucopyranosyl-2-{2-methoxy-4[1-(E)-propen-3-ol]phenoxyl}propane-3-ol(2)、benzyl alcohol β-D-(2′-O-β-D-xylopyranosyl)glucopyranoside(3)、腺嘌呤核苷(4)、白桦脂醇(5)、羽扇豆醇(6)、β-谷甾醇(7)。结论:化合物1～5为首次从黄猄草属植物中分离得到。Objective: To study chemical constituents of Championella sarcorrhiza C.Ling. Methods: The compounds in ethanol extract of Ch.sarcorrhiza were isolated and purified by column chromatography using silica gel,ODS,Sephadex LH-20 and HPLC,and their structures were identified by physiochemical properties and NMR. Results: seven compounds were identified as cornoside ( 1 ),(-)-(2 R )-1- O -β- D -glucopyranosyl-2-{2-methoxy-4[1-( E )-propen-3-ol]phenoxyl}propane-3-ol ( 2 ),benzyl alcohol β- D -(2′- O -β- D -xylopyranosyl )glucopyranoside ( 3 ),adenosine ( 4 ),Betulin ( 5 ), lupeol ( 6 ),β-sitosterol ( 7 ). Conclusion: Compounds 1 - 5 are isolated from the genus of Championella for the first time.

关 键 词：黄猄草属 菜头肾 化学成分 

分 类 号：R284.1[医药卫生—中药学]