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作 者:耿晓梅 李松[1] 王玉峰[1] 李向军[1] 王岳[1] 刘敏彦[1] GENG Xiao-mei;LI Song;WANG Yu-feng;LI Xiang-jun;WANG Yue;LIU Min-yan(Shijiazhuang Yiling Pharmaceutical Co.,Ltd.,Shijiazhuang,Hebei 050035,China)
机构地区:[1]石家庄以岭药业股份有限公司,河北石家庄050035
出 处:《中国现代中药》2019年第4期523-527,共5页Modern Chinese Medicine
基 金:河北省重大科技成果转化专项(15042504Z);石家庄科学研究与发展计划项目(161200097A)
摘 要:目的:利用多指标研究带式真空干燥技术在夏荔芪胶囊浸膏干燥工艺中的应用。方法:采用正交试验设计,确定带式真空干燥的最佳工艺条件,并以休止角、堆密度、黄芪甲苷及迷迭香酸含量等多指标评价法,进行带式真空干燥与真空烘箱干燥的对比实验。结果:确定带式真空干燥工艺参数为加热板温度115~130℃,加料速度20~25 L·h^(-1),履带速度为12~14 cm·min^(-1),真空度<0.1 Mpa。两种干燥工艺比较,带式真空干燥粉的休止角小于烘箱干燥粉,堆密度大于烘箱干燥粉,更适合于胶囊剂,且迷迭香酸含量更高,较多地保留了有效成分,同时节约了大量时间及蒸气消耗,也节省了人力成本。结论:带式真空干燥所得提取物含量都较高,适用于大生产。Objective: To explore the application of multi-indicator belt vacuum drying technology in the drying process of Xialiqi capsule extract. Methods: The orthogonal experimental design was used to determine the optimum process conditions for belt vacuum drying,and a comparative test of belt vacuum drying and vacuum oven drying was carried out by multi-index evaluation methods with angle of repos,bulk density and the active ingredient contents of astragaloside and rosmarinic acid as index. Results: The drying temperature of 115-130 ℃,the feed rate of 20-25 L · h ^-1 and the track speed of 12-14 cm · min ^-1 were the optimized parameters of belt vacuum drying process.Compared with the two drying processes,the vacuum drying powder showed a smaller angle of repose than the oven drying powder,and the bulk density was larger than the oven drying powder,which was more suitable for capsules,and the rosmarinic acid content was higher,and more active ingredients were retained.It saved a lot of time and steam consumption,as well as labor costs. Conclusion: The extract obtained by belt vacuum drying has a high content and is suitable for large production.
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