不同剂量配伍的三黄泻心汤总蒽醌含量比较研究  

Comparative study on the content of total anthraquinone in sanhuang Xiexin decoction with different dosages

作　　者：魏江存 秦祖杰 欧和生 谢臻[2] 陈勇[2] 李金洲[2] 陈子隽 韩倩 WEI Jiang-cun;QIN Zu-jie;OU He-sheng;XIE Zhen;CHEN Yong;LI Jin-zhou;CHEN Zi-juan;HAN Qian(Guangxi International Zhuang Medical Hospital,Nanning 530201,China;Guangxi University of Chinese Traditional Medicine,Nanning 530200,China)

机构地区：[1]广西国际壮医医院,南宁530201 [2]广西中医药大学,南宁530200

出　　处：《湖北农业科学》2019年第9期98-100,103,共4页Hubei Agricultural Sciences

基　　金：国家自然科学基金项目(81360524;81660701);广西自然科学基金项目(2016GXNSFAA380148)

摘　　要：建立紫外分光光度法测定不同剂量配伍的泻心汤中总蒽醌的含量。以大黄素为对照品,用浓度为1%的醋酸镁甲醇溶液作为显色剂,在512 nm波长处测定吸光度,计算不同剂量配伍的泻心汤总蒽醌的含量,最后比较其差异。结果表明,不同剂量配伍的泻心汤总蒽醌含量有差异,这可能与配伍后不同剂量的黄芩与黄连对大黄总蒽醌溶出率的影响有关,该方法可作为不同剂量配伍的中药方剂质量控制方法,为今后综合开发和利用不同剂量配伍的中药方剂提供参考依据。To establish a UV spectrophotometric method for the determination of total anthraquinones in Xiexin decoction with different doses. The content of total anthraquinone in Xiexin soup at different doses was calculated by determining at 512 nm wavelength and the solution of magnesium acetate with a concentration of 1% as a colorant. The content of the total anthraquinone in Xiexin soup with different doses was calculated, and the difference was compared. This method reveals the change of total anthraquinone content in Xiexin soup with different dosage. The content of total anthraquinones in Xiexin soup with different doses is different, which may affect the dissolution rate of total anthraquinone with different doses of Scutellariz baicalensis and Coptis chinensis. This method can be used as the quality control method of traditional Chinese medicine prescription in different dosages, and the combination of different dosage of traditional Chinese medicine in the future.

关 键 词：泻心汤 剂量配伍 紫外分光光度法 总蒽醌 

分 类 号：O657.32[理学—分析化学]