鱼金注射液辅助治疗小儿支气管肺炎临床疗效及对血清炎性因子的影响  

Clinical efficacy of Yujin injection in the treatment of bronchial pneumonia in children and its effect on serum inflammatory factors

作　　者：郑婵娟[1] 吴亚红[1] 王洪峰[1] ZHENG Chanjuan;WU Yahong;WANG Hongfeng(Department of Pediatrics,Jiamusi Central Hospital in Heilongjiang Province,Jiamusi 154002,China)

机构地区：[1]黑龙江省佳木斯市中心医院儿科

出　　处：《中国现代医生》2019年第12期63-65,共3页China Modern Doctor

摘　　要：目的探讨鱼金注射液辅助治疗小儿支气管肺炎的效果以及对血清炎性因子的影响。方法选取2017年8月~2018年7月我院收治60例小儿支气管肺炎患儿,采用随机数字表法分为两组,每组各30例,对照组的患儿行常规治疗,实验组的患儿在此基础上加用鱼金注射液。比较两组患儿的治疗效果、临床指标改善情况;采用ELISA法检测治疗前后两组患儿血清白细胞介素-6(IL-6)、白细胞介素-23(IL-23)、肿瘤转移因子-α(TNF-α)的水平。结果实验组的临床治疗效果显著高于对照组,差异具有统计学意义(P<0.05)。实验组患儿各项临床指标(气喘、发热、肺部啰音、住院、X线阴影)均优于对照组(P<0.05)。治疗前,两组患儿血清IL-6、IL-23、TNF-α的水平比较无显著差异(P>0.05);治疗后,两组患儿血清的IL-6、IL-23、TNF-α的水平较治疗前明显下降(P<0.05),但实验组的下降程度更优于对照组(P<0.05)。结论鱼金注射液用于治疗小儿支气管肺炎效果显著,可增加治疗效果,改善临床症状,减少住院时间,机制可能与降低体内的炎性因子有关。Objective To explore the effect of Yujin injection on the treatment of bronchopneumonia in children and its effect on serum inflammatory factors. Methods 60 children with pediatric bronchopneumonia admitted to our hospital from August 2017 to July 2018 were selected and randomly divided into two groups, with 30 patients in each group. The children in the control group were given routine treatment, and the children in the experimental group were given Yujin injection in addition. The therapeutic effects and clinical indicators of the two groups were compared. The levels of serum interleukin-6(IL-6), interleukin-23 (IL-23) and tumor metastasis factor-α(TNF-α) were measured by ELISA before and after treatment. Results The clinical treatment effect of the experimental group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). The clinical indicators (whee, fever, lung voice, hospitalization, and X-ray shadow) in the experimental group were superior to the control group(P<0.05). Before treatment, there was no significant difference in serum IL-6, IL-23 and TNF-α levels between the two groups(P>0.05). After treatment, the levels of serum IL-6, IL-23 and TNF-α in the two groups were significantly lower than those before treatment (P<0.05), but the decrease in the experimental group was better than that in the control group(P<0.05). Conclusion Yujin injection is effective in the treatment of bronchitis in children, which can increase the therapeutic effect, improve clinical symptoms and reduce hospitalization time. The mechanism may be related to the reduction of inflammatory factors in the body.

关 键 词：小儿支气管肺炎 鱼金注射液 炎性因子 白细胞介素 

分 类 号：R272[医药卫生—中医儿科学]