乙肝患者血清HBeAg与HBV-DNA定量的相关性分析  

Analysis on Correlation between HBeAg and HBV-DNA Levels in Patients with Hepatitis B

作　　者：蔡兴龙 CAI Xinglong(The Second Hospital of Nanjing, Nanjing University of ChineseMedicine, Jiangsu Nanjing 210003, China)

机构地区：[1]南京中医药大学附属南京医院/南京市第二医院检验科

出　　处：《河北医学》2019年第5期820-823,共4页Hebei Medicine

摘　　要：目的:研究乙型肝炎患者血清e抗原(HBeAg)与乙肝病毒DNA(HBV-DNA)定量的相关性。方法:选取586例HBsAg阳性乙肝患者血清样本,ELISA法检测HBeAg,实时荧光定量PCR检测HBV-DNA。结果:586例患者中HBeAg阳性组和阴性组中HBV-DNA检出率分别为86.19%和29.46%,两者差异有统计学意义(χ^2=194.46,P<0.05);HBeAg阳性组HBV-DNA含量显著高于阴性组,且随着HBeAg含量的增加,血清中HBV-DNA的载量随之增加(F=6.67,P<0.05)。结论:HBeAg和HBV-DNA两者具有一定的相关性,临床上应结合两者,可对乙肝患者HBV感染、复制、诊断做出更加准确的判断。Objective: To analyze the correlation between HBeAg and HBV-DNA levels in patients with hepatitis B. Methods: A totol of 586 HBsAg positive serum samples were selected. The levels of the HBeAg and HBV-DNA were measured by the ELISA and fluorometric PCR, respectively. The relationship between the markers were analyzed. Results: Among the 586 patients, the detection rate of HBV-DNA in HBeAg positive group and negative group was 86.19 % and 29.46 % respectively, which showed there was significant difference (χ^2=194.46, P<0.05) between the HBeAg positive group and negative group. The content of HBV-DNA in the HBeAg positive group was higher than in the HBeAg negative group. With the increase of the HBeAg content, the amount of HBV-DNA in the serum also increased(F=6.67, P<0.05). Conclusion: The HBeAg level is positive correlation with the HBV-DNA load. Simultaneous detection of HBeAg and HBV-DNA would be clinical most desirable.

关 键 词：乙型肝炎 HBV-DNA 乙型肝炎病毒E抗原 

分 类 号：R512.62[医药卫生—内科学]