NT-proBNP与SCr及SCysC比值对慢性肾衰竭合并心力衰竭的诊断价值  

Ratios of NT-proBNP to SCr and SCysC in diagnosis of chronic renal failure complicated with heart failure

作　　者：刘红丽 吴锡信[1] Liu Hongli;Wu Xixin(Department of Nephrology, Nanhua University, Hengyang 421001,China;Department of Nephrology, Guangdong Second People’s Hospital, Guangzhou 510317,China)

机构地区：[1]南华大学,衡阳421001 [2]广东省第二人民医院肾内科,广州510317

出　　处：《国际医药卫生导报》2019年第10期1587-1590,共4页International Medicine and Health Guidance News

摘　　要：目的探讨氨基末端B型钠尿肽原(NT-proBNP)与血清肌酐(SCr)、血清胱抑素C(SCysC)比值诊断慢性肾衰竭合并心力衰竭的临床价值。方法 随机选取广东省第二人民医院2016年8月至2018年11月临床诊断为无慢性肾衰或心衰、慢性肾衰竭、慢性心力衰竭及慢性肾衰竭合并心力衰竭患者各36、50、43、38例;对所有受试者测NT-proBNP、SCr和SCysC,并计算NT-proBNP/SCr、NT-proBNP/SCysC、eGFR,对所得数据进行相关分析与对比研究。结果 NT-proBNP仅分别与SCr、SCysC有独立的显著正相关(P<0.05)。4组NT-proBNP、NT-proBNP/SCr、NT-proBNP/SCysC比较行Kruskal-WallisH检验,显示4组NT-proBNP、NT-proBNP/SCr、NT-proBNP/SCysC比较差异均有统计学意义(均P<0.05),再行4组NT-proBNP、NT-proBNP/SCr、NT-proBNP/SCysC两两比较的秩和检验,显示4组NT-proBNP差异均有统计学意义(均P<0.05),但心衰组与慢性肾衰竭并心衰组NT-proBNP/SCr值、NT-proBNP/SCysC值比较差异无统计学意义(P值分别为0.064、0.320)。结论 NT-proBNP/SCr、NT-proBNP/SCysC可消除肾衰影响来评判慢性肾衰竭有无合并心衰。Objective To investigate the clinical value of the ratios of amino-terminal B type natriuretic peptide (NT-proBNP) to SCr and SCysC in the diagnosis of chronic renal failure complicated with heart failure. Methods 36 patients without chronic renal failure (CRF) or chronic heart failure (CHF), 50 with CRF, 43 with CHF, and 38 with CRF complicated with CHF were randomly selected from Guangdong Second People’s Hospital from August, 2016 to November, 2018. We measured SCr, SCysC, and NT-proBNP in all the subjects, and calculated NT-proBNP/SCr, NT-proBNP/SCysC, eGFR. All the data were analyzed and compared. Results NT-proBNP significantly, independently, and positively correlated with SCr and SCysC (P < 0.05). Kruskal- Wallis H test of NT-proBNP, NT-proBNP/SCr, and NT-proBNP/SCysC in the 4 groups showed that there were statistical differences in NT-proBNP, NT-proBNP/SCr, and NT-proBNP/SCysC among the four groups (P < 0.05). The rank sum test of NT-proBNP, NT-proBNP/SCr, and NT-proBNP/SCysC pairwise comparisons in the four groups showed that there were statistical differences in NT-proBNP among the four groups (P < 0.05), but no in NT-proBNP/SCr (P=0.064) and NT-proBNP/SCysC (P=0.320) between the chronic heart failure group and the chronic renal failure with complicated heart failure group. Conclusion NT-proBNP/SCr and NT-proBNP/SCysC can eliminate the effects of renal failure to determine whether chronic renal failure is associated with heart failure.

关 键 词：NT-PROBNP 慢性肾衰竭 心力衰竭 SCR SCysC 

分 类 号：R692.5[医药卫生—泌尿科学] R541.6[医药卫生—外科学]