ABZ/PPENK微球的制备及其表征  

Preparation and characterization of ABZ/PPENK microspheres

作　　者：靳钊 刘洪福 观姗姗 观文娜[2] 蹇锡高[3] JIN Zhao;LIU Hongfu;GUAN Shanshan;GUAN Wenna;JIAN Xigao(College of Polymer Science & Engineer,Qingdao University of Science & Technology,Qingdao 266042,China;Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences,Qingdao 266101,China;Department of Polymer Science & Materials,Dalian University of Technology,Dalian 116012,China)

机构地区：[1]青岛科技大学高分子科学与工程工程学院,山东青岛266000 [2]中国科学院青岛生物能源与过程研究所,山东青岛266000 [3]大连理工大学化工学院,辽宁大连116012

出　　处：《功能材料》2019年第5期5152-5154,5159,共4页Journal of Functional Materials

基　　金：山东省高等学校科学技术计划资助项目(J18KA005)

摘　　要：研究了乳化溶剂挥发法制备ABZ-PPENK微球的方法。利用扫描电镜、透射电镜、红外光谱表征了ABZ-PPENK微球的形态及结构,利用光学显微镜计算了微球的粒径分布,并筛分出不同粒径段的ABZ-PPENK微球,计算了微球的载药量与包封率。制备的ABZ-PPENK微球,表面光滑、球形圆整,制得的微球平均粒径为9.9μm,微球粒径接近正态分布,ABZ药物完全被包裹在PPENK微球之中,且载药量与包封率均较高。The preparation of ABZ-PPENK microspheres by emulsifying solvent evaporation method was studied. The morphology and structure of ABZ-PPENK microspheres were characterized by SEM,TEM and FT-IR. The particle size distribution of ABZ-PPENK microspheres was calculated by optical microscopy,and ABZ-PPENK microspheres with different particle size were screened out. The drug loading and encapsulation efficiency of the microspheres were calculated. The ABZ-PPENK microspheres prepared by this method had smooth surface and spherical shape. The average diameter of the microspheres was 9.9 μm. The diameter of the microspheres was close to normal distribution. ABZ drugs were completely encapsulated in the PPENK microspheres,and the drug loading and encapsulation efficiency were high.

关 键 词：阿苯达唑 聚芳醚腈酮 微球 制备 

分 类 号：O633[理学—高分子化学]