结核感染T细胞斑点试验诊断胸腔积液的价值  

Value of T-spot.TB test in diagnosis of pleural effusion

作　　者：张新宝 周瑛 姚超 洪青青 韩波波 荣雪松 张毕玲 梅益枝 ZHANG Xinbao;ZHOU Ying;YAO Chao;HONG Qingqing;HAN Bobo;RONG Xuesong;ZHANG Biling;MEI Yizhi(The Sixth Tuberculosis Department,Anhui Provincial Chest Hospital,Hefei 230022,China)

机构地区：[1]安徽省胸科医院结核六科,合肥230022

出　　处：《实用医学杂志》2019年第9期1492-1495,共4页The Journal of Practical Medicine

摘　　要：目的分析结核感染T细胞斑点试验诊断胸腔积液的价值。方法对2018年1-12月安徽省胸科医院临床诊断或确诊为结核性胸膜炎80例患者和36例非结核性胸膜炎进行回顾性分析。所有患者治疗前均行胸水T-SPOT.TB、血T-SPOT.TB、胸水ADA、血TB-Ab检测,并对其结果进行比较。结果胸水T-SPOT.TB在结核性胸膜炎的敏感度97.5%(78/80),高于血T-SPOT.TB80%(64/80)、胸水ADA67.5%(54/80)、血TBAb27.5%(22/80),差异均有统计学意义(均P <0.01)。胸水T-SPOT.TB在结核性胸膜炎的特异度91.67%(33/36)高于血T-SPOT.TB58.33%(21/36)、胸水ADA72.22%(26/36)、血TB-Ab55.56%(20/36)差异均有统计学意义(均P <0.05)。结论胸水T-SPOT.TB在结核性胸腔积液检测中具有较高的敏感度和特异度。Objective To analyze the value of T-SPOT.TB test in the diagnosis of pleural effusion. Methods Retrospective analysis was conducted on the data of 80 patients with and 36 patients without tuberculous pleurisy in Anhui Provincial Chest Hospital from January to December 2018. T-SPOT.TB test,blood T-SPOT. TB, chest water ADA,blood TB-Ab were detected in all patients before the treatment,and the results were compared. Results The sensitivity of T-SPOT.TB test in tuberculous pleurisy patients was 97.5%( 78/80), higher than that of T-SPOT. Tb(80%,64/80), that of hydrothorax(67.5%,54/80), and that of blood TB-Ab(27.5%,22/80)(all P < 0.01). The specificity of T-SPOT. TB test in pleural effusion was 91.67%( 33/36) higher than that of blood T-SPOT. Tb(58.33%,21/36), hydrothorax ADA(72.22%,26/36), and blood TB-Ab(55.56%,20/36), all of which had statistical significance(P < 0.05). Conclusion T-SPOT. TB test has high sensitivity and specificity in the detection of tuberculous pleural effusion.

关 键 词：结核 胸腔积液 酶联免疫斑点试验 腺苷脱氨酶 结核抗体 

分 类 号：R561.3[医药卫生—呼吸系统]