药物涂层球囊联合斑块旋切术与单纯药物涂层球囊治疗下肢动脉硬化闭塞症的效果对比  

Comparison of efficacy between drug-coated balloons combined with atherectomy and pure drug-coated balloons in the treatment of arteriosclerosis obliterans

作　　者：张东东 叶郁青 陈宁恒[1] 张闯[1] 欧阳璐 郭学利[1] ZHANG Dongdong;YE Yuqing;CHEN Ningheng;ZHANG Chuang;OUYANG Lu;GUO Xueli(Departmemt of Vascular Surgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院血管外科,郑州450052 [2]郑州大学第一附属医院生殖中心,郑州450052

出　　处：《实用医学杂志》2019年第10期1625-1629,共5页The Journal of Practical Medicine

摘　　要：目的对比分析药物涂层球囊(DCB)联合斑块旋切术与单纯DCB治疗下肢动脉硬化闭塞症(ASO)的有效性。方法回顾性分析2016年9月至2017年12月收治的125例确诊为ASO的患者临床资料,根据手术方式分为DCB扩张联合silverhawk斑块旋切40例(A组)和单纯DCB扩张85例(B组),比较术后6和12个月Rutherford分级、ABI、靶血管最小管腔直径(MLD)、远期管腔丢失(LLL)、再狭窄率、靶血管血运重建率(TLR)。结果剔除死亡及失访者后,最终A组38例,B组79例。两组患者一般情况、危险因素、靶病变长度差异无统计学意义(P> 0.05),术后6、12个月随访A组Rutherford分级、再狭窄率、LLL均低于B组,ABI、MLD均高于B组(P <0.05),TLR差异无统计学意义(P> 0.05)。结论对于ASO,DCB联合斑块旋切术相比单纯DCB具有更好的近中期疗效。Objective Comparative analysis of the efficacy of drug-coated balloons combined with atherectomy and pure drug-coated balloons for the treatment of arteriosclerosis obliterans. Methods We retrospectively analyzed the clinical data of 125 cases of patients with arteriosclerosis obliterans who were admitted from September 2016 to December 2017. According to the surgical method,there were 40 cases of drug-coated balloon expansion combined with silverhawk plaque resection(group A) and simple drug-coated balloon expansion in 85 cases (group B), comparing the Rutherford classification,A BI,minimum lumen diameter( MLD), long-term lumen loss(LLL), restenosis rate,target lesion revascularization(TLR) at 6 and 12 months after operation. Results After death and loss of visitors were excluded,38 cases in group A and 79 cases in group B were confirmed. There was no statistically significant difference in general condition,risk factors and target lesion length between the two groups(P > 0.05). The Rutherford classification,restenosis rate and LLL in group A were lower than those in group B,A BI and MLD were higher than those in group B(P < 0.05), and TLR was not statistically significant (P > 0.05). Conclusion For lower extremity arteriosclerosis obliterans,drug-coated balloon combined with atherectomy has a better near middle term effect than drug-coated balloons alone.

关 键 词：药物涂层球囊 斑块旋切 下肢动脉硬化闭塞症 再狭窄率 

分 类 号：R654.4[医药卫生—外科学]