氟比洛芬酯联合地塞米松用于PCNL手术超前镇痛及术后全身炎症反应综合征的临床研究  

Clinical analysis of the effect of flurbiprofen and DXM on preemptive analgesia and postoperative systemic inflammatory response syndrome for patients with PCNL

作　　者：陈清霞[1] 叶燕乐[1] 颜景佳[1] 谢文钦[1] 李顺元[1] 谢文吉[1] Chen Qingxia;Ye Yanle;Yan Jingjia(The First Hospital of Quanzhou Affiliated of Fujian Medical University,Quanzhou 362000)

机构地区：[1]福建医科大学附属泉州第一医院,福建泉州362000

出　　处：《中国现代医药杂志》2019年第5期9-12,共4页Modern Medicine Journal of China

基　　金：泉州市卫生局科研资助项目[编号:泉卫函(2014)267号]

摘　　要：目的观察评价氟比洛芬酯联合地塞米松用于经皮肾镜碎石取石术(PCNL)超前镇痛及术后全身炎症反应综合征的临床价值。方法选择我院2014年6月～2016年12月收治的180例符合纳入标准的择期行PCNL手术患者,随机分为A、B、C 3组,每组60例,A组于手术前15min静脉注射地塞米松10mg,B组于手术前15min静脉注射氟比洛芬酯1mg/kg,C组于手术前15min静注氟比洛芬酯1mg/kg复合地塞米松10mg。观察记录术后清醒时(T1)、术后4h(T2)、术后24h(T3)的疼痛评分及T3的CRP水平,术后24h内恶心呕吐等发生率,全身炎症反应综合征发生率。结果 C组术后各时间点疼痛VAS评分明显低于A、B组,差异有统计学意义(P<0.05);C组术后24h测定CRP水平明显低于A、B组,差异有统计学意义(P<0.05);C组全身炎症反应综合征发生率低于A、B组,差异有统计学意义(P<0.05)。结论 PCNL手术患者联合使用氟比洛芬酯和地塞米松对超前镇痛及抑制术后炎症反应综合征效果较好。Objective To observe the effect of flurbiprofen and DXM on preemptive analgesia and postoperative systemic inflammatory response syndrome (SIRS) for patients with percutaneous nephrolithotomy (PCNL).Methods 180 patients with PCNL were selected and randomly divided into three groups which received 10mg DXM(group A,60 cases) or 1mg/kg flurbiprofen (group B,60 cases)or 1mg/kg flurbiprofen combinated 10mg DXM (group C,60 cases)15 minutes before the surgery.Pain was scored by visual analogue scale (VAS)at 0h(T1),4h(T2),24h(T3)after surgery,adverse reactions,C reactive protein and the incidence rate of SIRS were recorded.Results There was statistically significant difference in the VAS scores among the three groups (P< 0.05).The VAS scores,C-reactive protein and the incidence rate of SIRS were lower in group C than the other two groups (P< 0.05).Conclusion Applying of flurbiprofen and DSM before the operation provides a better postoperative analgesia and fewer SIRS for the patients undergoing PCNL.

关 键 词：氟比洛芬酯 地塞米松 PCNL手术 超前镇痛 全身炎症反应综合征 

分 类 号：R699[医药卫生—泌尿科学]