早期糖尿病肾病患者血清Cys-C水平与eGFR的相关性  

CORRELATIONS BETWEEN SERUM CYSTATIN C LEVEL AND EGFR IN PATIENTS WITH EARLY DIABETIC NEPHROPATHY

作　　者：陈海兰 郭海霞[1] 高宇[2] CHEN Hai-lan;GUO Hai-xia;GAO Yu(the 981th Hospital of Joint Logistic Support Force of Chinese People's Liberation Army,Hebei Chengde 067000,China)

机构地区：[1]中国人民解放军联勤保障部队第九八一医院,河北承德067000 [2]承德医学院附属医院内分泌科

出　　处：《承德医学院学报》2019年第3期211-213,共3页Journal of Chengde Medical University

基　　金：承德市科学技术研究与发展计划项目(201606A090)

摘　　要：目的:探讨早期糖尿病肾病患者血清胱抑素水平与估计肾小球滤过率(estimated glomerular filtration rate,eGFR)的相关性。方法:60例早期糖尿病肾病患者根据血清胱抑素C水平分为糖尿病肾病A组33例和糖尿病肾病B组27例,选取同期我院70例健康体检者为参照C组。测定所有受试对象血清胱抑素C水平、血肌酐(serum creatinine,SCr),并根据MDRD公式计算eGFR;采用直线相关分析早期糖尿病肾病患者血清胱抑素C水平与eGFR的相关性。结果:早期糖尿病肾病A组和B组患者血清胱抑素C水平均明显高于参照C组,eGFR明显低于参照C组,差异有统计学意义(P<0.05);相关分析结果示,糖尿病肾病患者血清胱抑素C水平与eGFR呈负相关关系(r=-0.7193,P<0.05)。结论:早期糖尿病肾病患者血清胱抑素C水平与eGFR呈负相关关系,其有望成为早期诊断糖尿病肾病的预测因子。Objective:To investigate the correlations between serum cystatin C level and estimated glomerular filtration rate(eGFR)in patients with early diabetic nephropathy.Methods:60 patients with early diabetic nephropathy were divided into group A(n=33)and group B(n=27)according to serum cystatin C level;70 health examination people in our hospital during the same period were selected as group C.The serum cystatin C level,serum creatinine of all the subjects were detected and the eGFR was calculated using MDRD formula.Linear correlation analysis was used to analyze the correlations between serum cystatin C level and eGFR in patients with early diabetic nephropathy.Results:The serum cystatin C level of early diabetic nephropathy patients in group A and group B were all significantly higher than group C,while the eGFR were significantly lower(P<0.05).The serum cystatin C level of early diabetic nephropathy patients was negatively correlated with eGFR(r=-0.7193,P<0.05).Conclusions:The serum cystatin C level is negatively correlated with eGFR in patients with early diabetic nephropathy,which may be a predictor of early diagnosis of diabetic nephropathy.

关 键 词：糖尿病肾病 胱抑素C 估计肾小球滤过率(eGFR) 尿白蛋白肌酐比率 

分 类 号：R587.2[医药卫生—内分泌]