催化氢化还原法制备的N,N-双烷基化壳聚糖  

N,N-Dialkylated Chitosan Made by Catalytic Hydrogenation Reduction

作　　者：王林 辛梅华[1,2] 李明春[1,2] 刘旭光 周向恒 WANG Lin;XIN Meihua;LI Mingchun;LIU Xuguang;ZHOU Xiangheng(College of Materials Science and Engineering, Huaqiao University, Xiamen 361021, China;Engineering Research Center of Environment Friendly Functional Materials, Ministry of Education,Huaqiao University, Xiamen 361021, China)

机构地区：[1]华侨大学材料科学与工程学院,福建厦门361021 [2]华侨大学环境友好功能材料教育部工程中心,福建厦门361021

出　　处：《华侨大学学报（自然科学版）》2019年第3期350-355,共6页Journal of Huaqiao University(Natural Science)

基　　金：福建省海洋高新产业发展专项项目(201522);福建省自然科学基金资助项目(2016J01234);华侨大学研究生科研创新基金资助项目(17013081026)

摘　　要：以十二烷基磺酸钠为相转移剂,月桂醛与壳聚糖反应生成西夫碱,再通过钯碳(Pd/C)催化氢化还原西夫碱制备N,N-双十二烷基化壳聚糖衍生物.通过试验分析催化氢化反应时间、反应温度、Pd/C催化剂用量等因素对烷基化取代度的影响,并用元素分析、红外光谱、核磁共振氢谱等对产物进行表征.正交试验结果表明:催化氢化制备N,N-双十二烷基化壳聚糖的最佳催化氢化反应时间为24 h,反应温度为30℃,Pd/C催化剂的用量占壳聚糖总量的1%,制得的N,N-双十二烷基化壳聚糖的烷基化取代度为189%.Sodium dodecyl sulfonate was used as the phase transfer agent to react lauraldehyde with chitosan to generate schiff base. Then N,N-dialkyl chitosan derivatives were prepared by palladium carbon(Pd/C) catalytic hydrogenation reduction of schiff base. The effects of catalytic hydrogenation reaction time, reaction temperature, Pd/C catalyst dosage on the degree of alkylation substitution were studied. The products were characterized by elemental analysis, infrared spectroscopy and ~1H NMR spectroscopy. Orthogonal experiment results show that the best catalytic hydrogenation reaction conditions for the catalytic hydrogenation preparation of N,N-dialkyl chitosan are: reaction time 24 h, reaction temperature 30 ℃, Pd/C catalyst 1% of the total amount of chitosan. And the alkylation degree of N,N-dialkyl chitosan is 189%.

关 键 词：壳聚糖 催化氢化 烷基化 钯碳催化剂 

分 类 号：O636.1[理学—高分子化学]