血液相关指标与系统性红斑狼疮活动性分析  

An Analysis of Blood-Related Indicators with Systemic Lupus Erythematosus Activity

作　　者：刘丹 张舒 雷婷[1,4] 张曼[1,4,5] LIU Dan;ZHANG Su;LEI Ting;ZHANG Man(Peking University Ninth School of Clinical Medicine,Beijing 100038,China;Department of Clinical Laboratory,the Fourth Medical Center of General Hospital of PLA,Beijing 100038,China;Shengjing Hospital of China Medical University,Shenyang 110004,China;Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China;Beijing Key Laboratory of Urinary Cellular Molecular Diagnostics,Beijing 100038,China)

机构地区：[1]北京大学第九临床医学院,北京100038 [2]解放军总院第四医学中心检验科,北京100038 [3]中国医科大学附属盛京医院,辽宁沈阳110004 [4]首都医科大学附属北京世纪坛医院,北京100038 [5]尿液细胞分子诊断北京市重点实验室,北京100038

出　　处：《标记免疫分析与临床》2019年第5期741-744,共4页Labeled Immunoassays and Clinical Medicine

基　　金：北京市医院管理局“登峰”人才培养计划(编号:DFL20150701)

摘　　要：目的探讨白细胞(white blood cell,WBC)、红细胞(red blood cell,RBC)、血小板(platelet,PLT)、血红蛋白(hemoglobin,HB)、淋巴细胞绝对值(absolute lymphocyte value,Lym#)、平均血小板体积(mean platelet volume,MPV)与系统性红斑狼疮(systemic lupus erythematosus,SLE)病情活动性关系。方法随机收集2017年12月至2018年11月我院风湿免疫科SLE病人样本37例,根据SLE活动指数(systemic lupus erythematosus disease activity index,SLEDAI)分为活动组与非活动组,同时收集同期健康体检者22例作为对照组,检测样本的血常规相关指标Lym#、MPV、WBC、RBC、HB、PLT及血清补体3(serum complement 3,C3),红细胞沉降率(erythrocyte sedimentation rate,ESR),比较各指标之间的相关性。结果 SLE活动组与对照组比较,Lym#、C3、MPV、PLT、RBC、HB均小于对照组,差异具有统计学意义(P<0.05),两组间WBC无差异(P>0.05)。SLE非活动组与对照组间比较,Lym#、RBC、HB差异有统计学意义(P<0.05),二组间WBC、PLT、C3、MPV无差异(P>0.05)。SLE活动组与非活动组比较,活动组MPV、Lym#、C3、WBC、PLT、HB均低于非活动组,差异有统计学意义(P<0.05),ESR高于非活动组(P<0.05),两组间RBC无统计学差异(P>0.05)。WBC、RBC、HB、PLT、Lym#、MPV与SLE活动性指标SLEDAI、ESR呈负相关,与C3呈正相关。结论 WBC、RBC、HB、 PLT、Lym#、MPV可作为系统性红斑狼疮活动性的观察指标。Objective To investigate the relationships among White Blood Cell(WBC),Red blood cell(RBC),Platelet(PLT),Hemoglobin(HB),Absolute Lymphocyte Value(Lym#),Mean Platelet Volume(MPV)and Systemic Lupus Erythematosus(SLE)activity.Methods 37 SLE patients in Rheumatology and Immunology Department of our hospital were enrolled from December,2017 to November,2018.According to SLE Activity Index(SLEDAI),they were divided into the active group and the inactive group.At the same time,22 healthy people were collected as the control group.Level of Lym#,MPV,WBC,RBC,HB,PLT,C3 and ESR were measured and their correlations were analyzed respectively.Results Compared to the control group,Lym#,C3,MPV,PLT,RBC and HB decreased in the SLE active group and Lym#,RBC and HB were lower in the SLE inactive group.Contrast to the inactive group,MPV,Lym,C3,WBC,PLT and HB were lower and ESR was higher in the SLE active group.The differences were statistically significant( P<0.05 ).WBC,RBC,HB,PLT,Lym# and MPV were all negatively correlated with SLEDAI and ESR,while positively correlated with C3.Conclusion WBC,RBC,HB,PLT,Lym# and MPV could be used as indicators of SLE activity.

关 键 词：系统性红斑狼疮 疾病活动度 相关性 白细胞 红细胞 血红蛋白 淋巴细胞绝对值 平均血小板体积 

分 类 号：R593.241[医药卫生—内科学]